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. 1998 Feb;72(2):1632–1639. doi: 10.1128/jvi.72.2.1632-1639.1998

TABLE 5.

Summary of findings for p15E mutants

Envelope protein SU/TM processinga Incorporationb Cell-cell fusionc Titerc Phenotype
L441F + + +++ +++ WTd
L443R Processing/incorporation defective
L443A Low Processing/incorporation defective
L443I + Processing/incorporation defective
L445E + + Fusion defective
G449L Processing/incorporation defective
G449W Processing/incorporation defective
G449A Processing/incorporation defective
G449S Processing/incorporation defective
A457F + Low Fusion defective
G460V + + ++ + Nearly WT
G460E + + Fusion defective
T461P + + Fusion defective
T463A + + +++ + Nearly WT
T464A + + ++++ +++ Hyperfusogenic, but WT titer
T464I + + +++ ++ Nearly WT
T464K + + +++ ++ Nearly WT
M467E + + + No syncytia, but some titer
A468R + + +++ +++ WT
Q474E + + ++ + Nearly WT
L475R Processing/incorporation defective
a

+, SU and TM proteins are processed; −, only Pr85 is present. 

b

+, substantial incorporation; −, no incorporation; Low, low level of incorporation. 

c

++++, value greater than the wild-type value; +++, 50 to 100% of wild-type value; ++, 10 to 50% of wild-type value; +, 1 to 10% of the wild-type value. 

d

WT, wild type.