Table 3.
Clinical characteristics and demographics of patients underwent post-PTGBD early laparoscopic cholecystectomy (Early group) and immediate laparoscopic cholecystectomy (Immediate group)
| Early | Immediate | p value | |
|---|---|---|---|
| N = 18 | N = 1243 | ||
| Age (years) | |||
| Median (IQR) | 65 (53–78) | 52 (41–64) | 0.003 |
| Mean ± SEM | 63.7 ± 3.49 | 52.6 ± 0.43 | 0.002 |
| > 70 | 7 (38.9%) | 177 (14.2%) | 0.010 |
| Gender | 0.812 | ||
| Male | 9 (50.0%) | 685 (55.1%) | |
| Female | 9 (50.0%) | 558 (44.9%) | |
| Liver cirrhosis | 1 (5.6%) | 13 (1.0%) | 0.183 |
| ≥ 3 Comorbidities | 3 (16.7%) | 25 (2.0%) | 0.006 |
| Abdominal surgical history | 4 (22.2%) | 220 (17.7%) | 0.544 |
| Onset > 72 h | 4 (22.2%) | 282 (22.7%) | 1.000 |
| Fever (BT > 38°) | 10 (55.6%) | 199 (16.0%) | < 0.001 |
| SBP on admission | |||
| Median (IQR) | 154 (131–181) | 143 (125–161) | 0.167 |
| Mean ± SEM | 155 ± 7.1 | 145 ± 0.8 | 0.133 |
| Shock (< 90 mmHg) | 0 (0.0%) | 11 (0.9%) | 1.000 |
| Leukocyte (103/µL) | |||
| Median (IQR) | 13.2 (10.5–17.5) | 11.1 (8.2–14.6) | 0.050 |
| Mean ± SEM | 14.1 ± 1.24 | 11.8 ± 1.41 | 0.053 |
| Platelet count (103/µL) | |||
| Median (IQR) | 226.5 (187.0–258.5) | 233.0 (193.0–280.0) | 0.568 |
| Mean ± SEM | 230.5 ± 14.57 | 243.8 ± 2.92 | 0.583 |
| PT-INR | |||
| Median (IQR) | 1.10 (1.10–1.20) | 1.10 (1.00–1.20) | 0.134 |
| Mean ± SEM | 1.14 ± 0.021 | 1.12 ± 0.005 | 0.481 |
| Elevated LFT > 2 times | 2 (12.5%, n = 16) | 287 (24.4%, n = 1174) | 0.383 |
| Hyperbilirubinemia | 2 (11.8%, n = 17) | 156 (13.3%, n = 1175) | 1.000 |
| Tokyo Guidelines 2018 | 0.037 | ||
| Grade 1 | 7 (38.9%) | 823 (66.2%) | |
| Grade 2 | 10 (55.5%) | 389 (31.3%) | |
| Grade 3 | 1 (5.6%) | 31 (2.5%) | |
| Application of ERCP | 1 (5.6%) | 181 (14.6%) | 0.497 |
| Interval before operation | |||
| Post-PTGBD (day) | |||
| Median (IQR) | 5.8 (4.2–8.1) | ||
| Mean ± SEM | 6.5 ± 0.66 | ||
| Post-admission (day) | |||
| Median (IQR) | 6.3 (4.8–9.1) | 0.9 (0.6–2.5) | < 0.001 |
| Mean ± SEM | 7.0 ± 0.72 | 1.9 ± 0.06 | < 0.001 |
*PTGBD, percutaneous transhepatic gallbladder drainage; IQR, interquartile range; SEM, standard error of the mean; SBP, systolic blood pressure; PT-INR, international normalized ratio of prothrombin time; LFT, liver function tests; ERCP, endoscopic retrograde cholangiopancreatography
The results or descriptions highlighted in bold are solely intended to facilitate readers in readily identifying the key points in the tables