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. 2025 Sep 19;13(9):2299. doi: 10.3390/biomedicines13092299
ALI acute lung injury
ARDS acute respiratory distress syndrome
AEC alveolar epithelial cell
PF pulmonary fibrosis
AT1 cells alveolar type I epithelial cells
AT2 cells alveolar type II epithelial cells
ECM extracellular matrix
TNF-α tumor necrosis factor-α
IL-1β interleukin-1β
MOMP mitochondrial outer membrane permeabilization
FADD Fas-associated death domain protein
GSDMD gasdermin D
PAMPs pathogen-associated molecular patterns
DAMPs damage-associated molecular patterns
MLKL mixed lineage kinase domain-like protein
ROS reactive oxygen species
ENaC epithelial sodium channels
AQP5 aquaporin 5
HMGB1 High Mobility Group Box 1
TLR4 Toll-like receptor 4
JNK the c-Jun N-terminal kinase
MAPK mitogen-activated protein kinase
JAK Janus kinase
STAT3 Signal Transducer and Activator of Transcription 3
HATs histone acetyltransferases
lncRNAs Long non-coding RNAs
SDHA succinate dehydrogenase A
CXCL1 Chemokine Ligand 1
LPS lipopolysaccharide
BLM bleomycin
scRNA-seq single-cell RNA sequencing
VEGF Vascular Endothelial Growth Factor
VE-cadherin Vascular Endothelial Cadherin
GM-CSF granulocyte-macrophage colony-stimulating factor
SCFAs Short-chain fatty acids
TMAO trimethylamine N-oxide
FMT fecal microbiota transplantation
NAC N-acetylcysteine
AAV Adeno-associated virus
LNPs Lipid nanoparticles
PLGA poly(lactic-co-glycolic acid)
BALF bronchoalveolar lavage fluid
DATP damage-associated transient progenitor
TEER transepithelial electrical resistance