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. 2025 Sep 10;17(18):2960. doi: 10.3390/cancers17182960
Case Complication Description CDG
#1 Left renal cryoablation for a 2.8 cm enhancing left renal mass with subsequent left ureteral obstruction. A renal scan revealed a poorly functioning kidney even after a percutaneous nephrostomy placement. Subsequently underwent laparoscopic Radical Nephrectomy. Pathology showed no viable tumor cells. Died one month after nephrectomy due to suicide. 4
#5 Bilateral cryoablation was planned for bilateral RCC. After the first ablation of the right kidney, the patient developed pulmonary edema requiring reintubation and Lasix administration. The left-sided lesion was ablated five months later without complication. Loss to follow-up after four years of uncomplicated follow-up. 4
#36 Following left laparoscopic cryoablation, the patient developed intractable bleeding and later that evening underwent a completion nephrectomy. The biopsy was consistent with a clear cell RCC, and the nephrectomy showed no residual cancer. The patient was alive at last follow-up after 16 years with CKD stage II. 3
#39 After cryoablation in left kidney, the patient underwent workup for fever of unknown origin outside Duke. He underwent drainage of a healing cryoablation. Once came back to Duke for continuation of care, the reviewed outside hospital scans were consistent with hematoma and no evidence of abscess. Patient later underwent right Radical Nephrectomy (contralateral to cryoablation site) for synchronous RCC. Nephrectomy pathology report confirmed RCC. No recurrences in the left kidney which was treated by cryoablation. The patient was alive at 83 years of age after 17 years of follow-up. 3
#41 Following percutaneous ablation of left-sided renal mass in a case with longstanding history of diabetes, the patient developed left-sided crampy pain without fever or toxic appearance. Subsequent CT showed 10 ×10 cm perinephric abscess resulting in readmission and drainage by interventional radiologist colleagues. He remained disease-free nine years and died of intracranial hemorrhage at 81 years of age. 3
#117 Three months after left laparoscopic cryoablation in a SK patient, developed insidious onset of left pain and fever with subsequent creatinine increase to 7.5 mg/dL. Imaging confirmed ureteropelvic junction obstruction managed with percutaneous nephrostomy and following retrograde pyelography showed urothelial slough in the pelvis removed via ureteroscopy. 3
12 Cases
(side)
Port-site wound infection managed with antibiotics (#11, left; #71, right); flank pain, hematuria with clot passage managed by readmission (#27, left; #57, right); Intraoperative splenic injury and repair, post-ablation platelet transfusion (#33, left); retroperitoneal bleeding managed conservatively (#47, right; #76, left); sensory-neural hearing loss presumed to be secondary to intra-operative Gentamicin (#66, left); presumed post-operative transient ischemic attack (#67, right); Atrial fibrillation managed with fluids and medications (#86, left); hematocrit drop managed with transfusion (#94, left; #98, left). 2
11 Cases Flank pain (#13, #21, #43, #46, #80); dyspnea (#18 required furosemide for pulmonary effusion; #29 asthma exacerbation; #37 desaturation requiring BI-PAP; #90 atelectasis managed by incentive spirometry); hypokalemia managed by supplements (#8); fever with negative workup, self-limited (#69). 1