Case(s)	Biopsy-Proven Cases	Case(s)	Without Biopsy at Cryoablation
#21 #100	Repeat ablation and remained recurrence-free after seven years of follow-up.	#43 #113	Repeat ablations.
#69	Suspicious local enhancement was detected 30 months post-ablation, in the ablated zone. He underwent bilateral RN (one year on AS) outside of our center due to non-functioning kidneys, and the pathology confirmed RCC. He lived 8 years after RN and succumbed to septic shock at 72 years of age.	#3	Left RN for multiple enhancing lesions in the tumor 50 months post-ablation; path: oncocytoma.
#97	One patient who had simultaneous Gleason grade 3 + 4 prostate cancer and RCC developed metastasis after nine months of cryoablation. Subsequently, fine-needle aspiration confirmed metastatic RCC, and he succumbed to it 15 months post-ablation.	#92	PN; path: normal kidney tissue.
#105	One patient was treated with Partial Nephrectomy for ablation recurrence and later developed tumor extension to the pararenal fat and diaphragm. He was managed by excision of pararenal fat and parts of the diaphragm	#75	Bilateral RN; non-functional kidneys path: non-diagnostic for malignancy.