Algorithm 1 Identify Epistatic Interactions Using k2 Metric
Require: Maximum order mo; SNP combination x with mo SNPs generated by GPBSO; k2x as the k2 score of x
Ensure: Epistatic interaction of order within [2, mo) or no result
1:	Set l = mo
2:	while l > 1 do
3:	foundImprovement = false
4:	for each SNP index i in [0, l) do
5:	Create a new SNP combination xx of length l - 1 by excluding x[i]
6:	Compute k2xx as the k2 score for xx
7:	if k2xx < k2x then
8:	Update x to xx
9:	Update k2x to k2xx
10:	Decrement l by 1
11:	Set foundImprovement = true
12:	Exit the loop
13:	end if
14:	end for
15:	if not foundImprovement then
16:	Exit the loop
17:	end if
18:	end while
19:	if l > 1 then
20:	return x as the detected epistatic interaction
21:	end if