ADMET |
Absorption, Distribution, Metabolism, Excretion, and Toxicity |
AI |
Artificial Intelligence |
AUC |
Area Under the Curve |
BC |
Breast Cancer |
BMI |
Body Mass Index |
CADD |
Computer-Aided Drug Design |
CDER |
Center for Drug Evaluation and Research |
CDK |
Cyclin-Dependent Kinase |
CGRP |
Calcitonin Gene-Related Peptide |
CMap |
Connectivity Map |
EGFR |
Epidermal Growth Factor Receptor |
EHR |
Electronic Health Record |
ERs |
Estrogen Receptors |
ERK |
Extracellular Signal-Regulated Kinase |
FDA |
The United States Food and Drug Administration |
FOXM1 |
Forkhead Box M1 |
FZD |
Frizzled Receptor |
GNN |
Graph Neural Network |
HER2 |
Human Epidermal Growth Factor Receptor 2 |
HR |
Homologous recombination |
LINCS |
The Library of Integrated Network-Based Cellular Signatures |
MAPK |
Mitogen-Activated Protein Kinase |
MCF-7 |
Michigan Cancer Foundation-7 |
MDA-MB-231 |
MD Anderson Metastatic Breast 231 |
ML |
Machine Learning |
MLP |
Multi-Layer Perceptron |
mTOR |
The Mammalian Target of Rapamycin |
MTT |
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide |
NF-κB |
Nuclear Factor kappa B |
NLP |
Natural Language Processing |
NMF-DR |
Non-Negative Matrix Factorization-based Drug Repurposing |
PD-L1 |
Programmed Death-Ligand 1 |
PDPK1 |
Phosphoinositide-Dependent Kinase-1 |
PRs |
Progesterone Receptors |
QSAR |
Quantitative Structure–Activity Relationship |
ROC |
Receiver Operating Characteristic |
RWD |
Real World Data |
SERD |
Selective Estrogen Receptor Degrader |
SERM |
Selective Estrogen Receptor Modulator |
STITCH |
Search Tool for Interactions of Chemicals |
SUM149 |
Stephen University Mammalian cell line #149 |
TCGA |
The Cancer Genome Atlas |
TNBC |
Triple-Negative Breast Cancer |