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. 2025 Sep 10;61(9):1640. doi: 10.3390/medicina61091640
ADMET Absorption, Distribution, Metabolism, Excretion, and Toxicity
AI Artificial Intelligence
AUC Area Under the Curve
BC Breast Cancer
BMI Body Mass Index
CADD Computer-Aided Drug Design
CDER Center for Drug Evaluation and Research
CDK Cyclin-Dependent Kinase
CGRP Calcitonin Gene-Related Peptide
CMap Connectivity Map
EGFR Epidermal Growth Factor Receptor
EHR Electronic Health Record
ERs Estrogen Receptors
ERK Extracellular Signal-Regulated Kinase
FDA The United States Food and Drug Administration
FOXM1 Forkhead Box M1
FZD Frizzled Receptor
GNN Graph Neural Network
HER2 Human Epidermal Growth Factor Receptor 2
HR Homologous recombination
LINCS The Library of Integrated Network-Based Cellular Signatures
MAPK Mitogen-Activated Protein Kinase
MCF-7 Michigan Cancer Foundation-7
MDA-MB-231 MD Anderson Metastatic Breast 231
ML Machine Learning
MLP Multi-Layer Perceptron
mTOR The Mammalian Target of Rapamycin
MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
NF-κB Nuclear Factor kappa B
NLP Natural Language Processing
NMF-DR Non-Negative Matrix Factorization-based Drug Repurposing
PD-L1 Programmed Death-Ligand 1
PDPK1 Phosphoinositide-Dependent Kinase-1
PRs Progesterone Receptors
QSAR Quantitative Structure–Activity Relationship
ROC Receiver Operating Characteristic
RWD Real World Data
SERD Selective Estrogen Receptor Degrader
SERM Selective Estrogen Receptor Modulator
STITCH Search Tool for Interactions of Chemicals
SUM149 Stephen University Mammalian cell line #149
TCGA The Cancer Genome Atlas
TNBC Triple-Negative Breast Cancer