Table 5.
Adjusted Logistic Regression Models Evaluating the Association Between Heart Rate Variability Metrics and Region-Specific Brain Injury Based on Rutherford scoring system on Neonatal MRI During the First Week of Life.
| Region | HRV Metric | Adjusted OR | 95% CI | p-Value |
|---|---|---|---|---|
| Basal Ganglia/Thalamus (BG/T) | HF Power (First 24 h) | 0.94 | 0.87–0.99 | 0.10 |
| LF Power (Rewarming) | 0.97 | 0.94–0.99 | 0.08 | |
| LF/HF Ratio (Post-Rewarming) | 0.64 | 0.34–1.09 | 0.12 | |
| White Matter | LF Power (Rewarming) | 0.96 | 0.93–0.98 | 0.04 1 |
| Cortex | LF Power (Rewarming) | 0.97 | 0.94–0.99 | 0.08 |
| Cortex | HF Power (Rewarming) | 1.02 | 0.97–1.02 | 0.41 |
| Posterior Limb of Internal Capsule (PLIC) | HF Power (post-rewarming) | 1.00 | 0.98–1.02 | 0.83 |
| LF/HF Ratio (Post-Rewarming) | 0.67 | 0.41–1.04 | 0.09 |
Abbreviations: HF = high-frequency power (0.15–0.4 Hz); LF = low-frequency power (0.04–0.15 Hz); LF/HF = ratio of LF to HF power. Adjusted odds ratios (OR), 95% confidence intervals (CI), and p-values were obtained from binary logistic regression models, each adjusted for perinatal asphyxia severity (moderate/severe), hypoxic–ischemic encephalopathy severity (Sarnat II/III), and presence of electroclinical seizures. One model was estimated for each brain region using the Rutherford scoring system. Complete unadjusted models and covariate-specific effects are reported in Supplementary Tables S9–S12. 1 A p-value < 0.05 was considered statistically significant.