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. 1987 Aug 29;295(6597):517–520. doi: 10.1136/bmj.295.6597.517

Controlled multicentre therapeutic trial of an unrefined carbohydrate, fibre rich diet in Crohn's disease.

J K Ritchie 1, J Wadsworth 1, J E Lennard-Jones 1, E Rogers 1
PMCID: PMC1247426  PMID: 2822203

Abstract

Between 1 September 1980 and 31 August 1983, 352 patients with inactive or mildly active Crohn's disease but not taking drug treatment apart from sulphasalazine were entered from 40 hospitals into a prospective trial to assess the effects of two different diets on disease activity over two years. One hundred and sixty two patients were randomly allocated to take a diet unrestricted in sugar and low in fibre and 190 to a diet with little or no sugar and high in unrefined carbohydrate. No clear difference in clinical course was detected among patients who accepted the two different types of dietary advice.

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Selected References

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  1. Bingham S., McNeil N. I., Cummings J. H. The diet of individuals: a study of a randomly-chosen cross section of British adults in a Cambridgeshire village. Br J Nutr. 1981 Jan;45(1):23–35. doi: 10.1079/bjn19810074. [DOI] [PubMed] [Google Scholar]
  2. Brandes J. W., Lorenz-Meyer H. Zuckerfreie Diät: Ein neue Perspektive zur Behandlung des Morbus Crohn? Eine randomisierte, kontrollierte Studie. Z Gastroenterol. 1981 Jan;19(1):1–12. [PubMed] [Google Scholar]
  3. Harvey R. F., Bradshaw J. M. A simple index of Crohn's-disease activity. Lancet. 1980 Mar 8;1(8167):514–514. doi: 10.1016/s0140-6736(80)92767-1. [DOI] [PubMed] [Google Scholar]
  4. Heaton K. W., Thornton J. R., Emmett P. M. Treatment of Crohn's disease with an unrefined-carbohydrate, fibre-rich diet. Br Med J. 1979 Sep 29;2(6193):764–766. doi: 10.1136/bmj.2.6193.764. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Jones V. A., Dickinson R. J., Workman E., Wilson A. J., Freeman A. H., Hunter J. O. Crohn's disease: maintenance of remission by diet. Lancet. 1985 Jul 27;2(8448):177–180. doi: 10.1016/s0140-6736(85)91497-7. [DOI] [PubMed] [Google Scholar]
  6. Järnerot G., Järnmark I., Nilsson K. Consumption of refined sugar by patients with Crohn's disease, ulcerative colitis, or irritable bowel syndrome. Scand J Gastroenterol. 1983 Nov;18(8):999–1002. doi: 10.3109/00365528309181832. [DOI] [PubMed] [Google Scholar]
  7. Kasper H., Sommer H. Dietary fiber and nutrient intake in Crohn's disease. Am J Clin Nutr. 1979 Sep;32(9):1898–1901. doi: 10.1093/ajcn/32.9.1898. [DOI] [PubMed] [Google Scholar]
  8. Levenstein S., Prantera C., Luzi C., D'Ubaldi A. Low residue or normal diet in Crohn's disease: a prospective controlled study in Italian patients. Gut. 1985 Oct;26(10):989–993. doi: 10.1136/gut.26.10.989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Martini G. A., Brandes J. W. Increased consumption of refined carbohydrates in patients with Crohn's disease. Klin Wochenschr. 1976 Apr 15;54(8):367–371. doi: 10.1007/BF01469792. [DOI] [PubMed] [Google Scholar]
  10. Mayberry J. F., Rhodes J., Allan R., Newcombe R. G., Regan G. M., Chamberlain L. M., Wragg K. G. Diet in Crohn's disease two studies of current and previous habits in newly diagnosed patients. Dig Dis Sci. 1981 May;26(5):444–448. doi: 10.1007/BF01313588. [DOI] [PubMed] [Google Scholar]
  11. Mayberry J. F., Rhodes J., Newcombe R. G. Increased sugar consumption in Crohn's disease. Digestion. 1980;20(5):323–326. doi: 10.1159/000198454. [DOI] [PubMed] [Google Scholar]
  12. Miller B., Fervers F., Rohbeck R., Strohmeyer G. Zuckerkonsum bei Patienten mit Morbus Crohn. Verh Dtsch Ges Inn Med. 1976;82(Pt 1):922–924. [PubMed] [Google Scholar]
  13. O'Moráin C., Segal A. W., Levi A. J. Elemental diet as primary treatment of acute Crohn's disease: a controlled trial. Br Med J (Clin Res Ed) 1984 Jun 23;288(6434):1859–1862. doi: 10.1136/bmj.288.6434.1859. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Peto R., Pike M. C., Armitage P., Breslow N. E., Cox D. R., Howard S. V., Mantel N., McPherson K., Peto J., Smith P. G. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. Br J Cancer. 1977 Jan;35(1):1–39. doi: 10.1038/bjc.1977.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Rutgeerts P., Geboes K., Vantrappen G., Kerremans R., Coenegrachts J. L., Coremans G. Natural history of recurrent Crohn's disease at the ileocolonic anastomosis after curative surgery. Gut. 1984 Jun;25(6):665–672. doi: 10.1136/gut.25.6.665. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Silkoff K., Hallak A., Yegena L., Rozen P., Mayberry J. F., Rhodes J., Newcombe R. G. Consumption of refined carbohydrate by patients with Crohn's disease in Tel-Aviv-Yafo. Postgrad Med J. 1980 Dec;56(662):842–846. doi: 10.1136/pgmj.56.662.842. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Summers R. W., Switz D. M., Sessions J. T., Jr, Becktel J. M., Best W. R., Kern F., Jr, Singleton J. W. National Cooperative Crohn's Disease Study: results of drug treatment. Gastroenterology. 1979 Oct;77(4 Pt 2):847–869. [PubMed] [Google Scholar]
  18. Thornton J. R., Emmett P. M., Heaton K. W. Diet and Crohn's disease: characteristics of the pre-illness diet. Br Med J. 1979 Sep 29;2(6193):762–764. doi: 10.1136/bmj.2.6193.762. [DOI] [PMC free article] [PubMed] [Google Scholar]

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