AD	Applicability domain
AdaB	Adaptive Boosting
AhR	Aryl hydrocarbon receptor
AOP	Adverse outcome pathway
ASNNs	Associative neural networks
BFR	Brominated flame retardant
BMC	Biopartitioning micellar chromatography
CAR	Constitutive androstane receptor
CART	Classification and regression trees
CP	Conformal prediction
DBP	Phenolic disinfection byproduct
DIO	Iodothyronine deiodinase
DIO1	Type 1 deiodinase
DIO2	Type 2 deiodinase
DIO3	Type 3 deiodinase
DTC	Decision Tree Classifier
DUOX	Dual oxidase
EDC	Endocrine-disrupting chemical
EU	European Union
EURL ECVAM	European Union Reference Laboratory for Alternatives to Animal Testing
FAIR	Findable, Accessible, Interoperable, Reusable
FP	Fingerprint
HPA	Hypothalamic–pituitary–adrenal
HPG	Hypothalamic–pituitary–gonadal
HPT	Hypothalamic–pituitary–thyroid
HTS	High-throughput screening
IYD	Iodotyrosine deiodinase
kNN	k-nearest neighbours
LDA	Linear discriminant analysis
LMO	Leave more out
LOO	Leave one out
LR	Logistic regression
MCT	Monocarboxylate transporter
MCT10	Monocarboxylate transporter 10
MCT8	Monocarboxylate transporter 8
MDR1	Multidrug resistance protein 1
MIE	Molecular initiating event
MLR	Multiple linear regression
MRM	Multiple regression model
MRP2	Multidrug resistance-associated protein 2
MW	Molecular weight
NAMs	New approach methodologies
NIS	Sodium iodide symporter
NN	Neural network
OATP	Organic anion transporter polypeptide
OATP1A4	Organic anion transporter polypeptide 1A4
OATP1C1	Organic anion transporter polypeptide 1C1
OECD	Organisation for Economic Co-operation and Development
PBB	Polybrominated biphenyl
PBDE	Polybrominated diphenyl ether
PCA	Principal component analysis
PCB	Polychlorinated biphenyl
PCN	Polychlorinated naphthalene
PFAS	Per- and polyfluoroalkyl substances
PFC	Poly- and perfluorinated compound
PLR	Partial logistic regression
PLS	Partial least squares
PLS-DA	Partial least squares discriminant analysis
PPAR	Peroxisome proliferator-activated receptor
PS	Prediction entropy
PXR	Pregnane X receptor
QSAR	Quantitative structure–activity relationship
RF	Random forest
SHAP	Shapley additive explanation
SMOTEENN	Synthetic minority over-sampling technique-edited nearest neighbours
SVM	Support vector machine
T3	Triiodothyronine
T4	Thyroxine
TBG	Thyroid-binding globulin
TH	Thyroid hormone
THSDC	Thyroid hormone system-disrupting chemical
TPO	Thyroperoxidase
TR	Thyroid hormone receptor
TRHR	Thyrotropin-releasing hormone receptor
TSHR	Thyroid-stimulating hormone receptor
TTR	Transthyretin
XGB	Extreme gradient boosting