Table 4.
Distribution of LC cases and referents (Ref) according to a joint classification (VCM exposure and alcohol consumption or viral hepatitis infection).
| VCM < 2,500 ppm × years | VCM > 2,500 ppm × years | ||
|---|---|---|---|
| Alcohol < 60 g/day | |||
| Cases/Ref | 3/105 | 5/23 | |
| ORa (95% CI) | Reference | 6.64* (1.03–42.8) | |
| Alcohol > 60 g/day | |||
| Cases/Ref | 20/10 | 12/1 | |
| ORa (95% CI) | 144.1# (24.1–860.0) | 752.7# (55.3–10248.0) | |
| Alcohol summary | S = 5.05; AP = 80% | ||
| HbsAg/HCV negative | |||
| Cases/Ref | 20/113 | 13/23 | |
| ORb (95% CI) | Reference | 8.22* (1.57–43.0) | |
| HbsAg/HCV positive | |||
| Cases/Ref | 3/2 | 4/1 | |
| ORb (95% CI) | 67.2** (5.14–877.0) | 80.5** (3.67–1763.0) | |
| HbsAg/HCV summary | S = 1.08; AP = 7% | ||
Abbreviations: AP, proportion of disease attributable to interaction; S, Rothman’s synergy index for interaction.
a
OR adjusted for age and viral hepatitis infection.
b
OR adjusted for age and alcohol use.
*
p < 0.05,
**
p < 0.01, and
#
p < 0.001 by two-tailed t-test.