Table 2. Effect of areca nut and chrysanthemum oral gel on the area of ulcer and body weight changes in rats on the 2nd and 7th experimental days (n = 60).

Groups	Clinical evaluation
	Area of ulcer changes (mm 2)			Body weight changes (g)
	2 nd day	7 th day	p	2 nd day	7 th day	p
Negative control	9.34 ± 0.69	5.24 ± 8.89	0.131	118.58 ± 5.29	117.25 ± 6.19	0.291
Positive control	10.10 ± 0.17	0.03 ± 0,01	0.000*	109.58 ± 6.89	117.17 ± 7.50	0.005*
F1	10.04 ± 0.18	2.84 ± 0.44	0.000*	119.17 ± 13.27	115.33 ± 14.46	0.000*
F2	10.08 ± 0.16	0.11 ± 0.07	0.000*	116.83 ± 4.41	121.58 ± 4.87	0.010*
F3	10.08 ± 0.18	3.49 ± 0.42	0.000*	120.50 ± 4.32	117.75 ± 6.82	0.028*

Data are expressed as mean ± SD, * p < 0.05 (dependent t-test) denotes statistically significant differences between before and after treatment on the 2 ^nd and 7 ^th experimental days. Negative control: base gel; Positive control: triamcinolone acetonide orabase treatment; F1: 20% areca nut:80% chrysanthemum; F2: 50% areca nut:50% chrysanthemum; F3: 80% areca nut:20% chrysanthemum.