Table 4. Effect of areca nut and chrysanthemum oral gel on the area of ulcer and body weight changes in rats on the 2nd and 7th experimental days (n = 60).
| Groups | Clinical evaluation | |||||||
|---|---|---|---|---|---|---|---|---|
| Area of ulcer changes (mm 2) | Body weight changes (g) | |||||||
| 2 nd day | 7 th day | 95% CI | p | 2 nd day | 7 th day | 95% CI | p | |
| Negative control | 9.34 ± 0.69 | 5.24 ± 8.89 | 6.34, 6.84 | 0.000 | 118.58 ± 5.29 | 117.25 ± 6.19 | −1.31, 3.97 | 0.291 |
| Positive control | 10.10 ± 0.17 | 0.03 ± 0,01 | 9.96, 10.19 | 0.000 | 109.58 ± 6.89 | 117.17 ± 7.50 | −12.31, −2.84 | 0.005 |
| F1 | 10.04 ± 0.18 | 2.84 ± 0.44 | 6.89, 7.52 | 0.000 | 119.17 ± 13.27 | 115.33 ± 14.46 | 2.12, 5.54 | 0.000 |
| F2 | 10.08 ± 0.16 | 0.11 ± 0.07 | 9.86, 10.08 | 0.000 | 116.83 ± 4.41 | 121.58 ± 4.87 | −8.10, −1.39 | 0.010 |
| F3 | 10.08 ± 0.18 | 1.81 ± 0.71 | 6.25, 7.59 | 0.000 | 120.50 ± 4.32 | 117.75 ± 6.82 | 0.35, 5.14 | 0.028 |
Data are expressed as the mean ± SD, 95% CI, p < 0.05 dependent t-test, Results are representative of three independent experiments. Negative control: base gel treatment group; Positive control: triamcinolone acetonide treatment; F1: 20% areca nut:80% chrysanthemum; F2: 50% areca nut:50% chrysanthemum; F3: 80% areca nut:20% chrysanthemum.