Table 3.
Changepoint section-wise annual percent changes (APC) and their 95% confidence intervals (CI) of number of new children and rate of new children (unadjusted and adjusted for mother’s age) whose mother was diagnosed with cancer by cancer type in 1968–2022.
| Cancer | Number of new children (1968–2022) | Rate of new children, unadjusted for mother’s age (1968–2022) | Rate of new children, adjusted for mother’s age (1970–2022) | |||
|---|---|---|---|---|---|---|
| Changepoint section | APC (95% CI) | Changepoint section | APC (95% CI) | Changepoint section | APC (95% CI) | |
| All sites together (C00–43, C45–59, C64–96, D09.0–1, D32–33, D41–43, D45–47, D76) | 1996–2022 | 0.9 (0.8, 1.0) | 1996–2022 | 1.3 (1.2, 1.4) | 2007–2022 | 1.3 (1.0, 1.5) |
| 1984–1996 | 3.4 (2.9, 3.9) | 1984–1996 | 3.2 (2.7, 3.6) | 1997–2007 | 0.4 (–0.2, 1.0) | |
| 1968–1984 | –1.7 (–1.9, –1.4) | 1968–1984 | –0.3 (–0.5, 0.0) | 1970–1997 | 1.7 (1.5, 1.8) | |
| Brain, meninges and CNS (C70–72, D32–33, D42–43) | 2001–2022 | 0.1 (–0.4, 0.7) | 2001–2022 | 0.4 (–0.1, 0.9) | 2000–2022 | 0.3 (–0.2, 0.8) |
| 1968–2001 | 1.9 (1.6, 2.3) | 1968–2001 | 2.5 (2.1, 2.8) | 1970–2000 | 2.3 (1.9, 2.7) | |
| Breast (C50) | 1998–2022 | 0.3 (0.2, 0.5) | 1998–2022 | 0.7 (0.6, 0.9) | 1995–2022 | 0.3 (0.2, 0.5) |
| 1983–1998 | 4.1 (3.6, 4.6) | 1982–1998 | 4.0 (3.6, 4.4) | 1970–1995 | 3.0 (2.8, 3.3) | |
| 1968–1983 | –0.3 (–0.8, 0.2) | 1968–1982 | 1.2 (0.6, 1.8) | |||
| Colon and rectum (C18–20) | 1985–2022 | 1.8 (1.5, 2.1) | 1985–2022 | 2.0 (1.7, 2.3) | 1970–2022 | 1.1 (0.9, 1.3) |
| 1968–1985 | –1.7 (–2.8, –0.7) | 1968–1985 | –0.4 (–1.4, 0.5) | |||
| Female genital organs (C51–58) | 1996–2022 | 0.6 (0.3, 0.9) | 1996–2022 | 1.0 (0.7, 1.3) | 1982–2022 | 0.9 (0.8, 1.1) |
| 1985–1996 | 4.4 (3.0, 5.8) | 1984–1996 | 3.6 (2.5, 4.7) | 1970–1982 | –3.9 (–4.8, –3.1) | |
| 1968–1985 | –6.9 (–7.4, –6.3) | 1968–1984 | –5.7 (–6.3, –5.1) | |||
| Gallbladder, bile ducts (C23–24) | 1968–2022 | –1.4 (–2.0, –0.7) | 1968–2022 | –0.8 (–1.4, –0.2) | 1970–2022 | –1.3 (–2.0, –0.7) |
| Haematological (C81–96, D45–47, D76) | 1983–2022 | 1.2 (0.9, 1.4) | 1968–2022 | 1.4 (1.2, 1.5) | 1970–2022 | 1.2 (1.1, 1.4) |
| 1968–1983 | –0.3 (–1.2, 0.7) | |||||
| Kidney (C64) | 1981–2022 | 1.0 (0.5, 1.5) | 1968–2022 | 0.9 (0.6, 1.2) | 1970–2022 | 0.5 (0.2, 0.8) |
| 1968–1981 | –2.7 (–5.5, 0.1) | |||||
| Liver (C22) | 1968–2022 | 0.5 (–0.1, 1.1) | 1968–2022 | 1.0 (0.3, 1.6) | 1970–2022 | 0.9 (0.2, 1.6) |
| Lung, trachea (C33–34) | 1997–2022 | –0.2 (–1.0, 0.6) | 1968–2022 | 1.1 (0.9, 1.4) | 1997–2022 | –0.6 (–1.5, 0.3) |
| 1987–1997 | 4.8 (0.8, 9.0) | |||||
| 1970–1997 | 1.7 (0.9, 2.6) | |||||
| 1968–1987 | –1.9 (–3.3, –0.4) | |||||
| Melanoma of the skin (C43) | 2016–2022 | –5.8 (–8.7, –2.7) | 2016–2022 | –5.3 (–8.3, –2.3) | 2016–2022 | –5.9 (–8.8, –2.9) |
| 2006–2016 | 8.4 (7.0, 9.9) | 2005–2016 | 8.5 (7.0, 10.0) | 2007–2016 | 9.7 (8.0, 11.4) | |
| 1968–2006 | 2.0 (1.6, 2.3) | 1968–2005 | 2.5 (2.1, 2.8) | 1970–2007 | 2.2 (1.9, 2.5) | |
| Pancreas (C25) | 1984–2022 | 2.0 (1.4, 2.7) | 1984–2022 | 2.3 (1.6, 2.9) | 1970–2022 | 0.9 (0.5, 1.3) |
| 1968–1984 | –3.3 (–5.7, –0.8) | 1968–1984 | –1.7 (–4.1, 0.6) | |||
| Stomach (C16) | 1981–2022 | –2.1 (–2.6, –1.7) | 1968–2022 | –2.3 (–2.5, –2.0) | 1970–2022 | –2.6 (–2.8, –2.3) |
| 1968–1981 | –5.2 (–6.7, –3.7) | |||||
| Thyroid gland (C73) | 2017–2022 | –3.4 (–8.0, 1.5) | 2017–2022 | –2.8 (–7.5, 2.1) | 1985–2022 | 1.5 (1.3, 1.8) |
| 1987–2017 | 1.6 (1.3, 2.0) | 1985–2017 | 1.9 (1.6, 2.3) | 1970–1985 | 6.3 (4.9, 7.6) | |
| 1968–1987 | 4.6 (3.6, 5.6) | 1968–1985 | 6.0 (4.9, 7.2) | |||
CNS, central nervous system.