Table 5.
Colorectal cancer risk for selected organochlorines in relation to K-ras and p53 mutations.
| Wild-type
|
Mutated
|
||||
|---|---|---|---|---|---|
| No. (%) | OR (95% CI) | No. (%) | OR (95% CI) | p-Valuea | |
| K-ras | |||||
| p,p′-DDE | |||||
| Low | 16 (20) | 1.00 | 22 (44) | 1.00 | 0.012 |
| Medium | 34 (41) | 3.51 (1.49–8.24) | 15 (30) | 1.07 (0.42–2.72) | |
| High | 32 (39) | 2.78 (1.21–6.35) | 13 (26) | 0.72 (0.29–1.81) | |
| α-HCH | |||||
| Low | 28 (34) | 1.00 | 20 (40) | 1.00 | 0.55 |
| Medium | 27 (33) | 1.22 (0.57–2.61) | 10 (20) | 0.64 (0.25–1.66) | |
| High | 27 (33) | 2.16 (0.94–4.97) | 20 (40) | 1.75 (0.70–4.37) | |
| PCB-28 | |||||
| < LOD | 56 (68) | 1.00 | 35 (70) | 1.00 | 0.88 |
| > LOD | 26 (32) | 2.78 (1.24–6.25) | 15 (30) | 2.83 (1.13–7.06) | |
| PCB-118 | |||||
| < LOD | 26 (32) | 1.00 | 17 (34) | 1.00 | 0.42 |
| Medium | 25 (30) | 1.78 (0.81–3.90) | 14 (28) | 1.35 (0.53–3.43) | |
| High | 31 (38) | 2.27 (1.04–4.96) | 19 (38) | 1.64 (0.67–4.01) | |
| p53 | |||||
| p,p′-DDE | |||||
| Low | 12 (31) | 1.00 | 11 (19) | 1.00 | 0.047 |
| Medium | 16 (41) | 2.24 (0.81–6.16) | 20 (34) | 2.94 (1.11–7.76) | |
| High | 11 (28) | 1.09 (0.39–3.05) | 28 (47) | 3.44 (1.39–8.47) | |
| α-HCH | |||||
| Low | 18 (46) | 1.00 | 16 (27) | 1.00 | 0.045 |
| Medium | 10 (26) | 0.76 (0.29–2.01) | 17 (29) | 1.39 (0.58–3.35) | |
| High | 11 (28) | 1.22 (0.44–3.34) | 26 (44) | 3.44 (1.40–8.45) | |
| PCB-28 | |||||
| < LOD | 29 (74) | 1.00 | 44 (75) | 1.00 | 0.98 |
| > LOD | 10 (26) | 2.16 (0.79–5.91) | 15 (25) | 2.06 (0.85–5.01) | |
| PCB-118 | |||||
| < LOD | 14 (36) | 1.00 | 18 (31) | 1.00 | 0.19 |
| Medium | 13 (33) | 1.72 (0.65–4.53) | 13 (22) | 1.31 (0.53–3.26) | |
| High | 12 (31) | 1.40 (0.52–3.75) | 28 (47) | 2.79 (1.22–6.37) | |
a
p-Value for interaction between OC and the genetic alteration adjusted for age, sex, energy intake, and BMI; tests for differences in the OR between wild-type and mutated cases.