Table 6.
Colorectal cancer risk for PCB-118 in relation to K-ras and p53 mutation type.
| Transitionsa |
Transversionsa |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| No. (%) | OR (95% CI) | No. (%) | OR (95% CI) | p-Valueb | |||||
| PCB-118 | |||||||||
| < LOD | 20 (37) | 1.00 | 6 (18) | 1.00 | 0.071 | ||||
| Medium | 17 (32) | 1.09 (0.28–4.28) | 12 (35) | 3.29 (0.66–16.4) | |||||
| High | 17 (32) | 1.93 (0.41–9.09) | 16 (47) | 6.52 (1.16–36.6) | |||||
| Trend test p-valuec | 0.42 | 0.038 | |||||||
a
Mutations in K-ras and p53 classified as transitions (G:C→A:T) or transversions (G:C→T:A).
b
p-Value for interaction between PCB-118 and the mutation type; tests for differences in the OR between transitions and transversions.
c
Trend test p-value for the specific mutation type adjusted for age, sex, energy intake, and BMI.