Table 4.

Management of phase 3 of chronic hepatitis B virus infection

	APASL[11]	EASL[10]	AASLD[8,9]	INASL[12]	KASL[13]
Biopsy and treatment	Biopsy if ALT 1-2 × ULN or significant fibrosis on non-invasive assessment. Treat if > A2 or ≥ F2	Patients with HBeAg (-) disease and family history of HCC or cirrhosis, and extra-hepatic manifestations may be treated	Monitor	Monitor	Monitor

APASL: Asian Pacific Association for the Study of the Liver; EASL: European Association for the Study of the Liver; AASLD: American Association for the Study of Liver Diseases; INASL: Indian National Association for Study of the Liver; KASL: Korean Association for the Study of the Liver; ULN: Upper limit of normal; ALT: Alanine aminotransferase; HCC: Hepatocellular cancer.