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. 2025 Sep 15;16:1651482. doi: 10.3389/fimmu.2025.1651482

Table 2.

Efficacy of different treatment regimens.

Tumor type Treatment regimen Objective response rate (ORR) Disease control rate (DCR) Progression - free survival (PFS, months) Overall survival (OS, months)
Non - Small - Cell Lung Cancer Pembrolizumab + Pemetrexed + Platinum - based Chemotherapy 47.6% 76.4% 8.8 19.2
Non - Small - Cell Lung Cancer Traditional Chemotherapy (Pemetrexed + Platinum - based) 18.9% 49.4% 4.9 11.3
Non - Small - Cell Lung Cancer (EGFR - Mutated) Osimertinib as First - Line Treatment 71% 93% 18.9 Immature
Non - Small - Cell Lung Cancer (ALK - Fusion - Positive) Alectinib as First - Line Treatment 72.5% 96.2% 34.8 Not Reached
Non - Small - Cell Lung Cancer (HER2 - Mutated) Trastuzumab Deruxtecan Treatment 58.3% 81.3% 8.2 17.8
Small - Cell Lung Cancer Durvalumab in Consolidation Treatment after Concurrent Chemoradiotherapy 28.4% 66.3% 16.8 47.5
Small - Cell Lung Cancer Traditional Concurrent Chemoradiotherapy (Etoposide + Platinum - based) 16.0% 41.0% 5.6 28.7
HER2 - Positive Breast Cancer Trastuzumab + Chemotherapy 75% 89% No Specific Single Data No Specific Single Data
HER2 - Positive Breast Cancer Dual - Target Combination of Pertuzumab and Trastuzumab 80.2% 93.8% 18.5 56.5
HER2 - Positive Breast Cancer (Brain Metastases) DS - 8201 Treatment 64% No Specific Single Data No Specific Single Data No Specific Single Data
Triple - Negative Breast Cancer Sacituzumab Govitecan Monotherapy 35% 46% 4.8 11.8
Triple - Negative Breast Cancer (PD - L1 - Positive) Pembrolizumab + Chemotherapy (Albumin - Bound Paclitaxel) 21% - 35% No Specific Single Data 5.6 No Specific Single Data
Esophageal Cancer Nivolumab + Chemotherapy (Fluorouracil + Platinum - based) 45.9% 72.5% 7.7 13.2
Esophageal Cancer Traditional Chemotherapy (Fluorouracil + Platinum - based) 29.4% 55.7% 5.6 11.1