Table 3.
Application of Smart Polymer Based Ocular Delivery in Ophthalmology
| Ocular Disease | Polymer Based Nano Therapeutics | Important Feature | References |
|---|---|---|---|
| Vitrectomy | Injectable smart hydrogels | Comparable physiological features to those of natural aqueous vitreous | [112] |
| Age-related macular degeneration | Microsphere-hydrogel drug delivery systems | PLGA spheres the encapsulation of agents, for example ranibizumab. | [113] |
| Bio-responsive hydrogel | Characteristics of Rosihydrogel facilitated controlled dissolution of drug in reaction for localized enzyme. | [114] | |
| Diabetic retinopathy | Dual ligand hydrogel system (ICNPH) | [115] | |
| Glaucoma | Sol to gel chitosan-g-poly(N-isopropylacrylamide) | [116] | |
| Cataracts | PNIPAAm/PEG thermogel | A solitary drug-loaded GMS drop in rabbits resulted in intraocular pressure decreases akin to those achieved with brimonidine administered bi-daily as eye drops. | [96] |
| Fungal Keratitis | Initiated by pH at the site of fungal keratitis and capable of successfully eliminating both fungus and mature biofilms in an animal model of fungal keratitis | ||
| Uveitis | Nanoparticles of polyester | The research indicating the treatment’s efficacy in treating ocular inflammation. | [117] |
| Dry eye disease | Mucoadhesive thermogel | The extended duration of the gel’s presence for almost 14 days resulted in an ongoing dissolution of the encapsulating drug. | [108] |