TABLE 7.
Drugs with strong anticholinergic properties.
| Antidepressants |
| Amitriptyline |
| Amoxapine |
| Clomipramine |
| Desipramine |
| Doxepin (>6 mg/day) |
| Imipramine |
| Nortriptyline |
| Paroxetine |
| Antiemetics |
| Prochlorperazine |
| Promethazine |
| Antihistamines (first-generation) |
| Brompheniramine |
| Chlorpheniramine |
| Cyproheptadine |
| Dimenhydrinate |
| Diphenhydramine |
| Doxylamine |
| Hydroxyzine |
| Meclizine |
| Promethazine |
| Triprolidine |
| Antimuscarinics (urinary incontinence) a |
| Darifenacin |
| Fesoterodine |
| Flavoxate |
| Oxybutynin |
| Solifenacin |
| Tolterodine |
| Trospium |
| Antiparkinsonian agents |
| Benztropine |
| Trihexyphenidyl |
| Antipsychotics |
| Chlorpromazine |
| Clozapine |
| Olanzapine |
| Perphenazine |
| Antispasmodics |
| Atropine |
| Clidinium-chlordiazepoxide |
| Dicyclomine |
| Homatropine |
| Hyoscyamine |
| Scopolamine |
| Skeletal muscle relaxants |
| Cyclobenzaprine |
| Orphenadrine |
Note: This table is not a comprehensive list of all medications with anticholinergic properties.
a
Data on whether certain bladder antimuscarinics confer greater adverse cognitive effects than others lack consistent quality.
Oxybutynin has the best evidence for adverse cognitive effects. However, caution is warranted for all bladder antimuscarinics given their potential anticholinergic effects.20