Table 2.
Results of hematologic analysis in BPA, corn oil control, and MeP+PrP dose groups
| Control | MeP+PrP | p | ||||
|---|---|---|---|---|---|---|
|
|
|
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| Corn oil control Mean±SD | BPA (50 mg/kg bw/day) Mean±SD | 10 (mg/kg bw/day) Mean±SD | 100 (mg/kg bw/day) Mean±SD | 500 (mg/kg bw/day) Mean±SD | ||
| WBC (mm3) | 4.25±3.69 | 5.08±3.61 | 5.54±5.98 | 3.39±2.81 | 5.02±3 | 0.922 |
| RBC (mm3) | 11.02±1.54 | 5.96±0.74 | 7.14±2.04 | 8.09±2.49 | 7.25±2.62 | 0.103 |
| Mon# | 0.2±0.14 | 0.21±0.12 | 0.29±0.26 | 0.21±0.17 | 0.18±0.11 | 0.741 |
| Lenf# | 4±3.39 | 4.29±2.67 | 4.36±3.95 | 3.09±2.03 | 4.26±2.11 | 0.938 |
| Gran# | 0.15±0.07 | 1.56±0.97 | 1.86±1.87 | 1.07±0.75 | 1.39±0.66 | 0.536 |
| Mon% | 4.25±0.92 | 2.67±0.52 | 4±2.10 | 7.33±7.92 | 3.18±0.40 | 0.332 |
| Lenf% | 93.55±1.34 | 70±5.40 * | 66.67±15.49 * | 67.5±8.60 * | 71.12±4.24 | 0.033 |
| Gran% | 2.2±0.42 | 24.5±5.82 * | 26.33±13.26 * | 22.5±3.94 * | 23.7±3.47 * | 0.014 |
| Hct% | 38.55±6.29 | 41.5±4.93 | 50±13.99 | 42.67±14.49 | 43.97±13.51 | 0.796 |
| RDW% | 24.1±0.85 | 9.5±1.05 * | 16±3.49 * | 16±7.07 | 13±2.10 * | 0.004 |
| PDW% | 8.7±0.07 | 16.83±1.33 * | 24.83±9.37 | 13.33±4.18 | 15.93±1.14 * | 0.004 |
| Hb (g/dl) | 12.35±1.06 | 11.83±1.53 | 14.87±3.82 | 14.25±4.72 | 14.03±4.81 | 0.765 |
| MPV (fl) | 19.3±0.14 | 5.72±0.34 * | 6.57±1.77 * | 8.67±4.74 * | 6±0.65 * | <0.001 |
| MCV (fl) | 34.7±0.57 | 59.68±1.36 * | 61.47±1.78 * | 48.28±12.74 | 54.22±1.53 * | 0.001 |
| MCH (pg) | 9.7±0.14 | 17.38±0.49 * | 18.57±1.38 * | 15.92±2.94 * | 17.37±0.83 * | 0.002 |
| MCHC (g/dl) | 27.45±0.64 | 29.3±0.32 | 30.4±2.58 | 34.22±4.16 | 32.17±0.98 * | 0.014 |
: Statistically different from the corn oil control group (significance level p<0.05). The measured hematological parameters are: leukocyte amount - White Blood Cell (WBC), erythrocyte amount - Red Blood Cell (RBC), monocyte-granulocyte-lymphocyte amount (Mon#, Gran#, Lymph#), monocyte-granulocyte-lymphocyte percentages (%Mon, %Gran, %Lymph), hemoglobin amount in the blood (Hb), hematocrit value (Hct), Mean Corpuscular Volume (MCV), hemoglobin amount in erythrocytes - Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), Red Cell Distribution Width (RDW), Mean Platelet Volume (MPV), Platelet Distribution Width (PDW). MeP: Methylparaben; PrP: Propylparaben; BPA: Bisphenol-A; SD: Standard deviation.