Table 4.
The incidence of histopathological findings detected in the liver and kidney tissues of the control and dose groups
| Histopathological findings | Control | MeP+PrP | |||
|---|---|---|---|---|---|
|
|
|
||||
| Corn oil control | BPA (50 mg/kg bw/day) | 10 (mg/kg bw/day) | 100 (mg/kg bw/day) | 500 (mg/kg bw/day) | |
| Liver | |||||
| Congestion | 0/6 | 0/6 | 2/6 | 3/6 | 2/6 |
| Edema | 0/6 | 0/6 | 1/6 | 0/6 | 2/6 |
| Mononuclear cell infiltration | 0/6 | 1/6 | 1/6 | 2/6 | 1/6 |
| Sinusoidal expansion | 0/6 | 4/6 * | 4/6 * | 5/6 * | 3/6 |
| Degeneration in hepatic parenchyma | 0/6 | 3/6 | 2/6 | 3/6 | 2/6 |
| Lipid accumulation in cells | 0/6 | 2/6 | 0/6 | 1/6 | 0/6 |
| Picnotic cells | 0/6 | 1/6 | 1/6 | 0/6 | 0/6 |
| Necrotic lesions | 0/6 | 1/6 | 1/6 | 1/6 | 0/6 |
| Cytoplasmic vacuolization | 0/6 | 1/6 | 1/6 | 1/6 | 0/6 |
| Fibrous tissue formation | 0/6 | 1/6 | 1/6 | 1/6 | 0/6 |
| Cytoplasmic meltdown | 1/6 | 0/6 | 1/6 | 3/6 | 2/6 |
| Kidney | |||||
| Congestion | 1/6 | 3/6 | 4/6 | 5/6 * | 4/6 |
| Edema | 0/6 | 3/6 | 1/6 | 0/6 | 0/6 |
| Mononuclear cell infiltration | 0/6 | 2/6 | 1/6 | 2/6 | 1/6 |
| Glomerular atrophy | 1/6 | 6/6 * | 3/6 | 6/6 * | 3/6 |
| Degeneration in kidney structure | 0/6 | 5/6 | 1/6 | 1/6 | 0/6 |
| Tubular degeneration | 0/6 | 4/6 * | 3/6 | 5/6 * | 3/6 |
| Cell expulsion into the lumen | 0/6 | 6/6 * | 3/6 | 5/6 * | 3/6 |
| Necrotic lesions | 0/6 | 5/6 * | 4/6 | 1/6 | 0/6 |
| Fibrous tissue formation | 0/6 | 4/6 * | 0/6 | 3/6 | 2/6 |
| Hyperplasia | 0/6 | 3/6 | 2/6 | 1/6 | 1/6 |
Values are given as the number of rats with histopathological findings/number of rats examined in the group.
*
: Statistically different from the corn oil control group. Represents significance generated by Fisher Exact Test (significance level p<0.05). MeP: Methylparaben; PrP: Propylparaben; BPA: Bisphenol-A; SD: Standard deviation.