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. 2025 Sep 29;20(9):e0333176. doi: 10.1371/journal.pone.0333176

Fig 6. GeneChip analysis of hepatic gene expression in olfactory bulbectomized (OBX) mice chronically fed HFD.

Fig 6

C57BL/6J mice (10 weeks old) were subjected to OBX, and HFD feeding began 1 week later. The liver was isolated 25 weeks after HFD feeding (i.e., 26 weeks after olfactory bulbectomy). (A-B) GeneChip/IPA analysis of hepatic gene expression in OBX and sham-operated mice fed HFD. (A) Pathway related to changes in hepatic gene expression in OBX mice in the category of Molecular and cellular functions and Hepatotoxicity. Molecules mapped to each biological pathway are shown using gene symbols. n = 5/group. (B) The most highly up- or down-regulated genes in the liver of OBX mice. n = 5/group. (C-D) A reverse transcription-quantitative PCR analysis of the expression levels of the Vsig4 (C) and Onecut1 genes (D) in the livers of OBX mice fed HFD. n = 5/group. Values are the means ± SEM. *P < 0.05 assessed by the Student’s t-test.