TABLE 3.

Regions with QSM value significantly associated with plasma neurodegenerative protein in CSVD patients (voxel‐wise p < 0.001 and cluster‐wise FWE‐corrected p < 0.05).

Groups	Variable	Clusters	Cluster size	t value	p FWE value	Peak MINI coordinates (mm)			Brain regions (cluster size)
						X	Y	Z
All	Aβ42‐negative correlation	1	14746	5.481	<0.001	12	−33	72	Supp_Motor_Area_R (5308), Supp_Motor_Area_L (2135), Paracentral_Lobule_R (1501), Paracentral_Lobule_L (1042), Frontal_Sup_Medial_R (999), Frontal_Sup_R (971), Frontal_Sup_L (865), Postcentral_R (733), Precentral_R (315), Postcentral_L (912)
		2	1330	5.076	<0.001	−19	−36	76	Postcentral_L (912)
CSVD‐M	Aβ42‐negative correlation	1	1758	4.421	<0.001	10	7	64	Supp_Motor_Area_R (1388), Frontal_Sup_R (244)
		2	1074	5.276	0.001	13	−33	72	Paracentral_Lobule_R (501), Postcentral_R (453)
		3	1047	4.628	0.002	8	−17	68	Supp_Motor_Area_R (842)
		4	947	4.121	0.003	−3	−11	75	Supp_Motor_Area_L (674)
		5	670	4.305	0.022	−19	−36	76	Postcentral_L (536)
	Tau‐positive correlation	1	647	4.4	0.025	−2	52	−5	Frontal_Med_Orb_L (479)
	pTau181‐positive correlation	1	739	4.379	0.013	3	−10	73	Paracentral_Lobule_L (452)
CSVD‐S	Aβ42‐negative correlation	1	440	4.722	0.036	−46	12	0	Frontal_Inf_Oper_L (242)
		2	610	5.026	0.006	35	−49	44	Parietal_Inf_R (444)
	pTau217‐positive correlation	1	757	5.165	0.002	46	11	−1	Insula_R (444), Rolandic_Oper_R (200)

Abbreviations: CSVD, cerebral small vessel disease; Inf_Oper, inferior opercular frontal cortex; Frontal_Med_Orb, medial orbital frontal cortex; Frontal_Sup_Medial, superior medial frontal cortex; Frontal_Sup_R, superior frontal gyrus; FWE, family‐wise error; Insula, insular cortex; L, left hemisphere; MNI, Montreal Neurological Institute; Paracentral_Lobule, paracentral lobule; Parietal_Inf, inferior parietal lobule; Postcentral, postcentral gyrus; Precentral, precentral gyrus; QSM, quantitative susceptibility mapping; R, right hemisphere; Rolandic_Oper, Rolandic operculum; Supp_Motor_Area, supplementary motor area.