Table 3. Toxicities of EV and SG.

Toxicity	EV	SG	Notes
Peripheral neuropathy	Common, frequently severe (grade 3 or higher)	Less common	Off-target toxicity of EV due to MMAE
Dermatologic toxicity	Very common: rash, pruritus, severe reactions like SJS/TEN	Rare	On-target, off-site toxicity of EV due to Nectin-4 expression in skin for EV
Hematologic toxicity	Less common: neutropenia, anemia	Very common: neutropenia, anemia, thrombocytopenia	Off-target toxicity of SG due to SN-38 (active metabolite of irinotecan)
Gastrointestinal toxicity	Less common: diarrhea, nausea	Common: diarrhea, nausea, vomiting	Off-target toxicity of SG due to SN-38 (active metabolite of irinotecan)
Ocular toxicity	Common: dry eyes, blurred vision	Rare	On-target, off-site toxicity of EV due to Nectin-4 expression in ocular tissues
Hepatotoxicity	Common: mild elevations in liver enzymes	Less common: mild elevations in liver enzymes	Off-target toxicity of EV and SG
Pneumonitis	Less common	Less common	Off-target toxicity of EV and SG

EV = enfortumab vedotin, SG = sacituzumab govitecan, MMAE = monomethyl auristatin E, SJS/TEN = Stevens-Johnson syndrome/toxic epidermal necrolysis