Table 2. Diagnostic performance of time-dependent diffusion MRI–derived microstructural parameters for distinguishing benign and cancerous endometrial lesions.

Characteristic	AUC	Cutoff	Sensitivity, %	Specificity, %	PPV, %	NPV, %
Cellularity, cells × 10-3/µm2	0.86 [0.79, 0.93]	0.55	74.2 (46/62) [63.3, 85.1]	91.2 (62/68) [84.4, 97.9]	88.5 (46/52) [79.8, 97.1]	79.5 (62/78) [70.5, 88.4]
V in	0.83 [0.75, 0.90]	0.38	93.5 (58/62) [89.8, 100]	66.2 (45/68) [54.9, 77.4]	71.6 (58/81) [62.2, 81.7]	91.8 (45/49) [86.9, 100]
Diameter, µm	0.81 [0.74, 0.88]	0.31	96.8 (60/62) [92.4, 100]	58.8 (40/68) [47.1, 70.5]	68.2 (60/88) [58.5, 77.9]	95.2 (40/42) [88.8, 100]
Dex, µm2/msec	0.74 [0.65, 0.82]	0.42	85.5 (53/62) [76.7, 94.3]	60.3 (41/68) [48.7, 71.9]	66.2 (53/80) [55.9, 76.6]	82.0 (41/50) [71.4, 92.6]
Diffusivity at 0 Hz, µm2/msec	0.71 [0.62, 0.80]	0.48	71.0 (44/62) [59.7, 82.3]	69.1 (47/68) [58.1, 80.1]	67.7 (44/65) [56.3, 79.1]	72.3 (47/65) [61.4, 83.2]
Cellularity index, µm-1	0.70 [0.60, 0.79]	0.43	95.2 (59/62) [89.8, 100]	57.4 (39/68) [45.6, 69.1]	67.0 (59/88) [57.2, 76.9]	92.9 (39/42) [85.1, 100]
Diffusivity at 17 Hz, µm2/msec	0.67 [0.58, 0.77]	0.48	67.7 (42/62) [56.1, 79.4]	69.1 (47/68) [58.1, 80.1]	66.7 (42/63) [55.0, 78.3]	70.1 (47/67) [59.2, 81.1]
Diffusivity at 33 Hz, µm2/msec	0.62 [0.53, 0.72]	0.47	61.3 (38/62) [49.2, 73.4]	61.8 (42/68) [50.2, 73.3]	59.4 (38/64) [47.3, 71.4]	63.6 (42/66) [52.0, 75.2]

The values in parentheses are numerators and denominators, and the values in brackets are 95% confidence intervals.

AUC = area under the receiver operating characteristic curve, PPV = positive predictive value, NPV = negative predictive value, v_in = intracellular volume fraction, D_ex = extracellular diffusivity