Table 4.
Association of SHR with all-cause death, CVD death, and MACE by glucose status.
| Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | |
| All death | ||||||
| NGR | ||||||
| SHR | 14.38 (4.26 - 48.55) | <0.001 | 12.52 (3.36 - 46.66) | <0.001 | 1.43 (0.12 - 17.70) | 0.780 |
| T1 | ||||||
| T2 | 0.37 (0.14 - 0.99) | 0.047 | 0.63 (0.23 - 1.72) | 0.368 | 0.46 (0.12 - 1.83) | 0.271 |
| T3 | 0.79 (0.33 - 1.91) | 0.607 | 1.34 (0.55 - 3.23) | 0.517 | 0.85 (0.24 - 2.93) | 0.791 |
| Pre-DM | ||||||
| SHR | 3.97 (1.62 - 9.70) | 0.003 | 4.19 (1.73 - 10.11) | 0.001 | 2.50 (0.55 - 11.43) | 0.238 |
| T1 | Ref. | Ref. | Ref. | |||
| T2 | 0.76 (0.48 - 1.19) | 0.228 | 0.92 (0.59 - 1.45) | 0.734 | 1.22 (0.67 - 2.21) | 0.521 |
| T3 | 1.37 (0.87 - 2.15) | 0.171 | 1.55 (0.99 - 2.44) | 0.057 | 1.60 (0.81 - 3.14) | 0.173 |
| DM | ||||||
| SHR | 2.54 (1.83 - 3.52) | <0.001 | 2.41 (1.73 - 3.34) | <0.001 | 2.51 (1.52 - 4.15) | <0.001 |
| T1 | Ref. | Ref. | Ref. | |||
| T2 | 0.89 (0.67 - 1.18) | 0.423 | 0.95 (0.71 - 1.26) | 0.717 | 1.00 (0.66 - 1.51) | 0.994 |
| T3 | 1.52 (1.21 - 1.91) | <0.001 | 1.56 (1.24 - 1.97) | <0.001 | 1.50 (1.07 - 2.11) | 0.019 |
| CVD death | ||||||
| NGR | ||||||
| SHR | 54.06 (11.78 - 248.2) | <0.001 | 93.44 (14.62 - 597.4) | <0.001 | – | – |
| T1 | Ref. | Ref. | Ref. | |||
| T2 | – | – | – | – | – | – |
| T3 | – | – | – | – | – | – |
| Pre-DM | ||||||
| SHR | 6.14 (1.71 - 22.08) | 0.005 | 4.30 (1.23 - 15.05) | 0.022 | 6.28 (0.80 - 49.35) | 0.081 |
| T1 | Ref. | Ref. | Ref. | |||
| T2 | 0.74 (0.29 - 1.86) | 0.518 | 0.89 (0.35 - 2.24) | 0.801 | 1.20 (0.36 - 4.00) | 0.771 |
| T3 | 2.34 (1.03 - 5.29) | 0.042 | 2.56 (1.13 - 5.83) | 0.025 | 2.67 (0.81 - 8.82) | 0.106 |
| DM | ||||||
| SHR | 3.53 (1.95 - 6.38) | <0.001 | 3.26 (1.79 - 5.93) | <0.001 | 2.75 (1.04 - 7.28) | 0.042 |
| T1 | Ref. | Ref. | Ref. | |||
| T2 | 0.69 (0.36 - 1.34) | 0.276 | 0.74 (0.38 - 1.42) | 0.362 | 0.75 (0.30 - 1.84) | 0.523 |
| T3 | 2.11 (1.33 - 3.33) | 0.001 | 2.14 (1.35 - 3.39) | 0.001 | 1.97 (1.03 - 3.80) | 0.042 |
| MACE | ||||||
| NGR | ||||||
| SHR | 4.64 (1.79 - 12.04) | 0.002 | 5.04 (1.94 - 13.10) | 0.001 | 1.70 (0.42 - 6.79) | 0.455 |
| T1 | Ref. | Ref. | Ref. | |||
| T2 | 0.79 (0.41 - 1.52) | 0.473 | 0.98 (0.50 - 1.89) | 0.942 | 0.90 (0.39 - 2.06) | 0.803 |
| T3 | 0.97 (0.52 - 1.84) | 0.937 | 1.27 (0.67 - 2.41) | 0.463 | 0.99 (0.44 - 2.21) | 0.974 |
| Pre-DM | ||||||
| SHR | 1.60 (0.80 - 3.18) | 0.183 | 1.86 (0.96 - 3.60) | 0.065 | 1.60 (0.80 - 3.18) | 0.183 |
| T1 | Ref. | Ref. | Ref. | |||
| T2 | 0.85 (0.65 - 1.09) | 0.198 | 0.96 (0.75 - 1.25) | 0.778 | 1.12 (0.83 - 1.53) | 0.455 |
| T3 | 0.98 (0.74 - 1.31) | 0.911 | 1.10 (0.83 - 1.47) | 0.516 | 1.12 (0.77 - 1.62) | 0.550 |
| DM | ||||||
| SHR | 1.68 (1.29 - 2.18) | <0.001 | 1.63 (1.25 - 2.11) | <0.001 | 1.68 (1.29 - 2.18) | <0.001 |
| T1 | Ref. | Ref. | Ref. | |||
| T2 | 0.87 (0.72 - 1.05) | 0.145 | 0.91 (0.75 - 1.09) | 0.305 | 0.95 (0.75 - 1.22) | 0.711 |
| T3 | 1.23 (1.05 - 1.44) | 0.011 | 1.27 (1.08 - 1.48) | 0.003 | 1.26 (1.01 - 1.56) | 0.038 |
Model 1: univariate model; Model 2: adjust for age, and sex; Model 3: adjust for age, sex, BMI, SBP, smoking, drinking, ACS, TC, LDL-c, eGFR, and HR.
SHR, stress hyperglycemia ratio; CVD, cardiovascular disease; MACE, major adverse cardiovascular events; NGR, normal glucose regulation; pre-DM, prediabetes mellitus; DM, diabetes mellitus; HR,hazard ratio.