Table 2.
Univariate survival analysis of all patients with IDH-wildtype glioma.
| Variables | OS | PFS | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | |
| Age, years (>50 vs ≤50) | 1.914 | 1.587–2.307 | <0.0001 | 1.813 | 1.495–2.200 | <0.0001 |
| Sex (male vs female) | 1.159 | 0.964–1.394 | 0.1223 | 1.180 | 0.9751–1.429 | 0.0946 |
| Pre-operation KPS (≤80 vs >80) | 1.564 | 1.296–1.887 | <0.0001 | 1.483 | 1.222–1.801 | <0.0001 |
| EOR (non-GTR vs GTR) | 2.267 | 1.891–2.717 | <0.0001 | 2.047 | 1.698–2.469 | <0.0001 |
| grade III vs grade II | 3.268 | 2.276–4.693 | <0.0001 | 3.127 | 2.170–4.506 | <0.0001 |
| grade IV vs grade II | 4.942 | 4.022–6.074 | <0.0001 | 4.641 | 3.753–5.739 | <0.0001 |
| MGMT (Unmethylated vs Methylated) | 1.077 | 0.889–1.305 | 0.4417 | 1.031 | 0.846–1.256 | 0.7642 |
| Treatment after surgery (Chemo-radiation vs other treatment) |
1.097 | 0.901–1.336 | 0.3588 | 1.211 | 0.990–1.481 | 0.0679 |
OS, overall survival; PFS, progression free survival; HR, hazard ratio; CI, confidence interval; KPS, Karnofsky Performance Score; EOR, extent of resection; GTR, gross total resection; MGMT, promoter region of the DNA repair enzyme O6-methylguanine-DNA methyltransferase.