Table 1. Optimization catalysts and mediators for aerobic oxidation reaction conditions of 2-phenyl 2,3-dihydroquinazolin-4(1H)-one^a.

Entry	LDHzyme	Mediator	Yield (%)
1	CuFeZn-LDHzyme	DDQ	65
2	CuFeMn-LDHzyme	DDQ	98
3	CuFe-LDHzyme	DDQ	50
4	MnFe-LDHzyme	DDQ	57
5	MnCu-LDHzyme	DDQ	68
6	—	DDQ	45
7	CuFeMn-LDHzyme	—	55
8	CuFeMn-LDHzyme	DDQ	70b
9	CuFeMn-LDHzyme	4-Tert	45
10	CuFeMn-LDHzyme	DTBC	55
11	CuFeMn-LDHzyme	4-Phenyl urazole	98

^aReaction conditions unless stated otherwise: substrate (1 mmol), LDHzyme (140 mg), mediator (10 mol%), CH₃CN (3 mL) under O₂ (balloon), and 18 h; the bolds represent the effective reaction conditions.

^bThe reaction was performed under open flask.