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. 2025 Sep 30;15(43):36237–36248. doi: 10.1039/d5ra03505h

Table 3. Synthesis of quinazolinone derivatives via aerobic oxidation using CuMnFe LDHzyme/DDQ and CuMnFe-LDHzyme/4-phenyl urazole catalytic systema.

Entry Substrate Product DDQ 4-Phenyl urazole
Time (h) Yield (%) Time (h) Yield (%)
1 graphic file with name d5ra03505h-u2.jpg graphic file with name d5ra03505h-u3.jpg 18 98 20 98
2 graphic file with name d5ra03505h-u4.jpg graphic file with name d5ra03505h-u5.jpg 17 98 18 96
3 graphic file with name d5ra03505h-u6.jpg graphic file with name d5ra03505h-u7.jpg 16.5 98 17 98
4 graphic file with name d5ra03505h-u8.jpg graphic file with name d5ra03505h-u9.jpg 18 92 18.5 85
5 graphic file with name d5ra03505h-u10.jpg graphic file with name d5ra03505h-u11.jpg 18 89 20 82
6 graphic file with name d5ra03505h-u12.jpg graphic file with name d5ra03505h-u13.jpg 18 85 19.5 82
7 graphic file with name d5ra03505h-u14.jpg graphic file with name d5ra03505h-u15.jpg 19 85 20 80
8 graphic file with name d5ra03505h-u16.jpg graphic file with name d5ra03505h-u17.jpg 23 24 77 80
9 graphic file with name d5ra03505h-u18.jpg graphic file with name d5ra03505h-u19.jpg 22 75 24 70
10 graphic file with name d5ra03505h-u20.jpg graphic file with name d5ra03505h-u21.jpg 22 70 24 68
a

Reaction Conditions: substrate (1 mmol), CuMnFe-LDHzyme (140 mg), mediator (10 mol%), CH3CN (3 mL) under O2 (balloon).