Skip to main content
. 2025 Sep 16;68(18):19143–19152. doi: 10.1021/acs.jmedchem.5c01193

1. Minimum Inhibitory Concentration (MIC) of the Novltex Analogues (110) against MRSA along with Their Configuration.

graphic file with name jm5c01193_0008.jpg

  analogues configuration
 
synthesized Novltex analogues Phe1 Leu2 Lys3 Ser4 Thr5 Ala6 Leu7 Leu8/Ile8 MIC against MRSA ATCC 33591 (μg/mL)
1 L D D L L L D L 8
2 L D D L D L D L 32
3 D L L D D L L L 32
4 L D D L D L L L 2–4
5 D L D L D L L L >32
6 L D L D D L L L >32
7 D D L L D L L L 32
8 L L L L D L L L >32
9 D D D D D L L L 16
10 L D D L D L L L 8
vancomycin                 0.5–1
a

Indicates the presence of l-Ile8 for analogue 10.