Table 2.
The baseline of included studies
| Characteristic | CVD | Studies | RR/MD (95% CI) | Heterogeneity | |
|---|---|---|---|---|---|
| Age, mean (SD), y | |||||
| 64.7 (12.8) | Yes | 11 | MD = 0.34[−0.17, 0.84]; P = 0.19 | I²=100% | |
| 46.6 (16.1) | No | 11 | |||
| BMI, mean (SD), kg/m2 | |||||
| 24.8 (4.2) | Yes | 5 | MD = 0.09[−0.08, 0.26]; P = 0.30 | I²=98% | |
| 26.4 (5.1) | No | 5 | |||
| Gender, number (%) | |||||
| Male | 8,359,011 (4.9) | Yes | 8 | RR = 1.02[0.93, 1.11]; P = 0.22 | I²=99% |
| Female | 6,974,096 (4.1) | Yes | 8 | ||
| Male | 73,154,350 (43.2) | No | 8 | ||
| Female | 80,943,661 (47.8) | No | 8 | ||
| Smoke, number (%) | |||||
| Yes | 8,797 (9.0) | Yes | 4 | RR = 1.13[0.92, 1.40]; P = 0.22 | I²=99% |
| No | 13,856 (14.1) | Yes | 4 | ||
| Yes | 59,056 (60.3) | No | 4 | ||
| No | 16,263 (16.6) | No | 4 | ||
| Alcohol, number (%) | |||||
| Yes | 5,551 (9.0) | Yes | 2 | RR = 0.87[0.70, 1.08]; P = 0.21 | I²=99% |
| No | 12,591 (20.5) | Yes | 2 | ||
| Yes | 28,162 (45.9) | No | 2 | ||
| No | 15,070 (24.6) | No | 2 | ||
| Diabetes, number (%) | |||||
| Yes | 40,239 (6.7) | Yes | 6 | RR = 1.88[1.22, 2.90]; P = 0.0042 | I²=99% |
| No | 119,150 (19.8) | Yes | 6 | ||
| Yes | 59,451 (9.9) | No | 6 | ||
| No | 382,289 (63.6) | No | 6 | ||
| Hypertension, number (%) | |||||
| Yes | 73,145 (12.2) | Yes | 5 | RR = 1.35[1.09, 1.68]; P = 0.0058 | I²=99% |
| No | 86,000 (14.3) | Yes | 5 | ||
| Yes | 160,703 (26.8) | No | 5 | ||
| No | 279,892 (46.7) | No | 5 | ||
| CKD, number (%) | |||||
| Yes | 15,960 (1.5) | Yes | 2 | RR = 3.03[1.18, 7.77]; P = 0.02 | I²=99% |
| No | 168,395 (16.2) | Yes | 2 | ||
| Yes | 14,366 (1.4) | No | 2 | ||
| No | 839,071 (80.9) | No | 2 | ||
| Family History of CRC, number (%) | |||||
| Yes | 136 (0.5) | Yes | 2 | RR = 0.94[0.80, 1.12]; P = 0.49 | I²=0 |
| No | 1,490 (5.2) | Yes | 2 | ||
| Yes | 2,515 (8.7) | No | 2 | ||
| No | 24,614 (85.6) | No | 2 | ||
| Get married, number (%) | |||||
| Yes | 8,905,798 (5.3) | Yes | 2 | RR = 0.97[0.85, 1.11]; P = 0.66 | I²=99% |
| No | 6,245,704 (3.7) | Yes | 2 | ||
| Yes | 86,855,102 (51.6) | No | 2 | ||
| No | 66,462,936 (51.6) | No | 2 | ||
| Education upon College number (%) | |||||
| Yes | 7,375,136 (4.4) | Yes | 2 | RR = 0.78[0.73, 0.83]; P < 0.0001 | I²=89% |
| No | 7,776,366 (4.6) | Yes | 2 | ||
| Yes | 98,471,081 (58.5) | No | 2 | ||
| No | 54,846,957 (32.5) | No | 2 | ||
| Pathological Stage, number (%) | |||||
| Ⅰ+Ⅱ | 111 (21.3) | Yes | 3 | RR = 0.94[0.74, 1.19]; P = 0.61 | I²=31% |
| Ⅲ+Ⅳ | 156 (30.0) | Yes | 3 | ||
| Ⅰ+Ⅱ | 113 (21.7) | No | 3 | ||
| Ⅲ+Ⅳ | 140 (27.0) | No | 3 | ||
| Number of Lymph Node Dissection, mean (SD) | |||||
| 17.6 (4.6) | Yes | 3 | MD= −0.02[−0.31, 0.27]; P = 0.89 | I²=63% | |
| 17.7 (4.0) | No | 3 | |||
| Location, number (%) | |||||
| Colon | 1,011 (10.9) | Yes | 3 | RR = 1.13[1.09, 1.16]; P = 0 | I²=0 |
| Rectal | 334 (3.6) | Yes | 3 | ||
| Colon | 5,476 (59.0) | No | 3 | ||
| Rectal | 2,456 (26.5) | No | 3 | ||
Abbreviations: SD, Standard Deviation; CVD, cardiovascular disease; BMI, Body Mass Index; CKD, Chronic Kidney Disease