Table 3.

Effect of CVD on CRC

Characteristics	Studies	Cases/Subjects	Relative Risk/Mean Difference (95% CI)	Model	Heterogeneity
Risk of CRC CVD† HF† HF in female† HFrEF in female HFpEF in female† CHD Postoperative prognosis Surgical time/min Surgical blood loss/ml Postoperative exhaust time/day Postoperative hospital stay/day All complications Clavien-Dindo complication grade Incision Infection Anastomotic Leakage Intestinal Obstruction Abdominal Infection Abdominal Bleeding HF ACS Arrhythmias† All-cause mortality in CVD† All-cause mortality in AF All-cause mortality in HF†	11 4 2 2 2 3 3 2 2 2 4 2 2 2 2 2 2 2 3 3 5 2 3	99,150/21,729,218 15,174,575/153,279,600 10,805/148,807 70/1415 173/1312 15,147,500/153,237,790 267/253 196/192 196/192 196/192 348/1,390 196/192 196/192 196/192 196/192 196/192 196/192 196/192 267/253 267/253 117,810/20,955,728 2,061,081/18,531,591 1,530,786/19,112,649	RR = 1.24[1.04, 1.48]; P = 0.02 RR = 1.39[1.03, 1.89]; P = 0.0307 RR = 2.32[1.39, 3.88]; P = 0.0014 RR = 1.00[0.22, 4.55]; P = 0.9996 RR = 2.54[1.52, 4.24]; P = 0.0004 RR = 1.26[0.74, 2.14]; P = 0.4032 MD = 0.10[−0.07, 0.27]; P = 0.246 MD = 0.16[−0.09, 0.41]; P = 0.1984 MD = 0.04[−0.16, 0.24]; P = 0.41 MD= −0.03[−0.29, 0.23]; P = 0.8724 RR = 1.46[0.81, 2.63]; P = 0.21 RR = 0.56[0.27, 1.18]; P = 0.1295 RR = 1.19[0.63, 2.24]; P = 0.5857 RR = 2.1[0.83, 5.37]; P = 0.1194 RR = 0.98 [0.38, 2.54]; P = 0.9674 RR = 0.96[0.30, 3.10]; P = 0.9473 RR = 0.97[0.18, 5.37]; P = 0.9721 RR = 2.45[0.47, 12.87]; P = 0.2904 RR = 3.32[0.89, 12.35]; P = 0.073 RR = 3.05[1.27, 7.35]; P = 0.0127 RR = 1.56[1.26, 1.94]; P < 0.01 RR = 2.36[0.66, 8.51]; P = 0.1887 RR = 1.68[1.49, 1.90]; P < 0.00001	DL DL DL DL DL DL DL DL DL DL DL DL DL DL DL DL DL DL DL DL DL DL DL	I2 = 88%; P < 0.01 I2 = 81%; P = 0.0011 I2 = 72%; P = 0.0583 I2 = 76%; P = 0.0407 I2 = 55%; P = 0.1354 I2 = 80; P = 0.0070 I2 = 0; P = 0.7753 I2 = 31; P = 0.2281 I2 = 0; P = 0.9788 I2 = 37; P = 0.2082 I2 = 0; P = 0.84 I2 = 0; P = 0.6776 I2 = 0; P = 0.9763 I2 = 0; P = 0.2916 I2 = 0; P = 0.6333 I2 = 0; P = 0.5186 I2 = 0; P = 0.4401 I2 = 0; P = 0.7828 I2 = 0; P = 0.8090 I2 = 0; P = 0.8547 I2 = 84; P < 0.01 I2 = 100%; P < 0.0001 I2 = 73%; P = 0.025

Significant results are marked with an dagger†

CI, confidence intervals; HF, Heart Failure; HFrEF, Heart Failure with Reduced Ejection Fraction; HFpEF, Heart Failure with Preserved Ejection Fraction; AMI, Acute Myocardial Infarction; CHD, Coronary Heart Disease; AF, Atrial Fibrillation; CVD, cardiovascular disease; ACS, Acute Coronary Syndrome