Table 2.

The addition of PALS to baseline risk models.

Study	Subgroup	N	Baseline model	Baseline C-statistics	Baseline + PALS C-statistics	NRI (95% CI)
Jenner et al. (20)	AR	80	Age, Gender, LVEDVi, LVESVi, LVEF, LVGLS, Stroke work, DD grade, E/e′	0.78	0.80	NR
Lai et al. (19)	AR	352	Age, CCI, Gender, LVGLS	0.81	0.82	NR
Benfari et al. (25)	AS	67	Age, Gender, BSA, HT, DM	0.73	0.82	NR
Thellier et al. (6)	AS	387	Age, Gender, BSA, BMI, SBP, DBP, HT, DM, CAD, CCI	0.77	0.79	NR
Lee et al. (18)	AS	923	Age, Sex, HT, AF, history of HF, IHD, COPD, hemoglobin, AVR as a time-dependent covariate	NR	NR	0.224 (0.07–0.38)

AF, atrial fibrillation; AVR, aortic valve replacement; BMI, body mass index; BSA, body surface area; CAD, coronary artery disease; CCI, Charlson comorbidity index; COPD, chronic obstructive pulmonary disease; DM, diabetes mellitus; DBP, diastolic blood pressure; DD, diastolic dysfunction; HF, heart failure; HT, hypertension; IHD, ischemic heart disease; LVEDVi, left ventricular end diastolic volume index; LVESVi, left ventricular end-systolic volume index; LVEF, left ventricular ejection fraction; LVGLS, left ventricular global longitudinal strain; NRI, net reclassification index; NR, not reported; SBP, systolic blood pressure.