TABLE 2.

MICs of voriconazole, fluconazole, itraconazole, and amphotericin B against quality control and reference isolates

Isolate	Antifungal agent	MIC range (μg/ml)
		Present study	Referencea
C. parapsilosis (ATCC 22019)	Voriconazole	0.06–0.12	NA
	Fluconazole	2–4	2–8
	Itraconazole	0.12–0.25	0.06–0.25
	Amphotericin B	0.5–2	0.25–1.0
C. krusei (ATCC 6258)	Voriconazole	0.25	NA
	Fluconazole	32–64	16–64
	Itraconazole	0.25–0.5	0.12–0.5
	Amphotericin B	2	0.5–2
P. variotii (ATCC 22319)	Voriconazole	0.06–0.12	NA
	Itraconazole	0.06–0.5	0.03–1
	Amphotericin B	0.25–0.5	0.25–1

^aEstablished reference MIC ranges for the two NCCLS QC Candida strains (25). The MIC range for P. variotii was obtained in two previous collaborative studies by the NCCLS Subcommittee (9, 10). NA, not available.