TABLE 2.

Summary of genotype results for 477 codons associated with resistance to RT and PR inhibitors by OLA and sequencing of HIV-1 samples

Genotypic results (SEQ→OLA) (n)b	No. of codons with RT amino acid mutation which confers resistance to:					No. of codons with PR amino acid mutation which confers resistance to PR inhibitors
	NRT inhibitorsa			NNRT inhibitorsa
	Q151M	M184V	T215Y	K103N	Y181C	D30N	V82A	L90M
HIV-1 non-B subtypes and RF samples
MT (SEQ)→MT (OLA) (29)	0	7	4	12	1	0	1	4
MT (SEQ)→WT (OLA) (0)	0	0	0	0	0	0	0	0
MT (SEQ)→INDET (OLA) (3)	0	2	0	1	0	0	0	0
WT (SEQ)→WT (OLA) (103)	14	11	6	9	12	21	14	16
WT (SEQ)→MT (OLA) (5)	0	0	0	1	3	0	0	1
WT (SEQ)→INDET (OLA) (16)	1	1	2	0	3	1	7	1
Total (156)	15	21	12	23	19	22	22	22
HIV-1 subtype B samples
MT (SEQ)→MT (OLA) (81)	10	21	8	16	7	2	5	12
MT (SEQ)→WT (OLA) (0)	0	0	0	0	0	0	0	0
MT (SEQ)→INDET (OLA) (5)	0	0	1	1	0	0	3	0
WT (SEQ)→WT (OLA) (193)	27	15	14	18	18	40	34	27
WT (SEQ)→MT (OLA) (34)	1	7	2	2	17	1	1	3
WT (SEQ)→INDET (OLA) (8)	1	1	2	1	2	0	0	1
Total (321)	39	44	27	38	44	43	43	43

^aNRT, nucleoside reverse transcriptase; NNRT, nonnucleoside reverse transcriptase.

^bMT, mutant; WT, wild type; INDET, indeterminate (negative for both wild-type and mutant genotypes).