Table 7.

ADME analysis of compounds using QikProp.

Compound	CNS	QPPCaco	QPPMDCK	QPlogBB	QPlogHERG	QPlogKhsa	%HOA	accptHB	donorHB	MW	QPlog Po/w	Rule of Five
6a	2	1010.403	3600.163	0.634	−7.014	−0.481	87.777	14.7	0	650.941	3.418	1
6b	0	4310.69	10,000	0.281	−6.055	−0.423	100	12.7	0	595.862	3.866	1
6c	−1	1339.799	4415.227	−0.342	−6.43	−0.562	89.984	14.7	0	649.91	3.421	1
6d	0	4393.656	10,000	0.246	−7.419	0.593	100	12.2	1	675.924	6.082	2
6e	0	3012.326	10,000	0.024	−6.36	0.215	100	12.2	1	607.873	4.596	1
6f	−1	2306.102	7979.758	−0.314	−8.03	0.962	100	12.2	2	710.996	6.6	2
6 g	0	4277.614	10,000	0.38	−6.308	−0.219	100	13.2	0	653.96	4.568	1
Streptomycin	−2	0.129	0.034	−4.48	−4.991	−1.733	0	25.25	16	581.579	−5.564	3
Ciprofloxacin	0	12.632	9.192	−0.684	−3.255	0.026	48.297	6	1	331.346	0.28	0
Tetracyclin	−2	3.859	1.348	−2.096	−5.018	0.023	19.593	8.25	3	444.44	−0.835	1
Chloramphenicol	−2	80.632	201.127	−1.4	−2.816	−0.819	67.532	6.9	3	323.132	1.104	0