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. 2025 Sep 30;25:882. doi: 10.1186/s12888-025-07217-0

Table 3.

Relationship between family environment and DNA methylation levels in patients

CpG_1/3/8 CpG_2 CpG_4 CpG_5 CpG_7 CpG_9 CpG_10
Roles rρ/r −0.401a −0.213a 0.114a 0.169a 0.384a 0.269a 0.079a
P 0.042* 0.296 0.579 0.409 0.053 0.184 0.702
General functioning rρ/r 0.088b −0.629b −0.085a 0.020b 0.192a 0.323a 0.273a
P 0.669  < 0.001** 0.679 0.922 0.347 0.108 0.177
Affective involvement rρ/r 0.024b −0.200b −0.248a −0.011b 0.495a 0.176a −0.220a
P 0.908 0.328 0.222 0.956 0.010* 0.391 0.280
Father's emotional warmth t/Z −0.297c −3.815c −1.324d −0.702c −0.279d −0.838d −0.423c
P 0.769  < 0.001** 0.185 0.489 0.780 0.402 0.676
Father's punishment t/Z −0.570c 3.034c −1.198d −1.054c −1.298c −0.184d −0.673d
P 0.574 0.006** 0.231 0.302 0.207 0.854 0.501
Father's rejection t/Z 0.569c 2.276c −0.237d −0.169c −0.531d −0.196d −1.091c
P 0.574 0.032* 0.813 0.867 0.595 0.845 0.286
Father's overprotection t/Z −1.537d −0.418c −1.165d −2.268d −0.046c −2.151d 0.744c
P 0.124 0.680 0.244 0.023* 0.964 0.031* 0.464
Mother's excessive interference t/Z 0.605c 0.327c −0.059d −2.430c 0.000d −1.175c −1.164d
P 0.551 0.747 0.953 0.023* 1.000 0.268 0.244
Mother's rejection t/Z 0.861c 1.715c −0.249d −1.393d 0.615c −0.071c −2.241d
P 0.398 0.099 0.803 0.164 0.545 0.944 0.025*
Mother's preference t/Z 0.516c −0.656c −2.189d −0.468c 0.823c −1.084c −0.108d
P 0.610 0.518 0.029* 0.644 0.418 0.289 0.914

CpG Cytosine-phosphate-Guanine

aSpearman's rank correlation

bPearson’s correlation

ct-tests

dMann-Whitney U tests

P, P-value; *P < 0.05, **P < 0.01