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. 2025 Sep 30;25:882. doi: 10.1186/s12888-025-07217-0

Table 4.

Association of Family environment and DNA methylation levels with symptom severity

		Obsessive thoughts	Compulsive behaviors	Y-BOCS total scores
CpG_6	r_ρ/r	0.757^a	0.337^a	0.676^b
CpG_6	P	< 0.001^**	0.010^*	< 0.001^**
CpG_9	r_ρ/r	0.272^a	0.027^a	0.214^a
CpG_9	P	0.039^*	0.838	0.106
CpG_12	r_ρ/r	0.324^a	0.142^a	0.278^a
CpG_12	P	0.013^*	0.289	0.035^*
Problem-Solving	r_ρ/r	0.447^a	−0.009^b	0.413^a
Problem-Solving	P	0.022^*	0.964	0.036^*
Communication	r_ρ/r	0.442^a	0.034^b	0.417^a
Communication	P	0.024^*	0.868	0.034^*
Affective Responsiveness	r_ρ/r	0.603^a	0.064^b	0.601^a
Affective Responsiveness	P	0.001^**	0.755	0.001^**
General Functioning	r_ρ/r	0.483^a	0.147^b	0.571^a
General Functioning	P	0.012^*	0.472	0.002^**
Father’s punishment	t/Z	0.578^c	−3.269^c	−1.135^d
Father’s punishment	P	0.569	0.003^**	0.256
Mother’s preference	t/Z	2.738^c	0.566^c	2.182^c
Mother’s preference	P	0.011^*	0.577	0.039^*

^aSpearman's rank correlation

^bPearson’s correlation

^ct-tests

^dMann-Whitney U tests

P, P-value; *P < 0.05, **P < 0.01