TABLE 2.

Lesion Border Delineation and Lesion Contrast: Comparison of Paired Differences Among the Different Analysis Groups

Assessed by	Characteristic	Unenhanced MRI(n = 19)	ACE-MBCA Enhanced MRI (n = 19)	ACE-MBCA Combined MRI (n = 19)	Gadobenate Dimeglumine Combined MRI (n = 18)
LBD
Reader 1	n	19	19	19	16
	Mean (SD)	1.8 (0.8)	2.7 (1.1)	2.4 (0.8)	2.4 (0.6)
	Min, max	1.0, 3.0	1.0, 4.0	1.0, 4.0	1.0, 3.0
	95% CI	1.4, 2.2	2.2, 3.2	2.0, 2.8	2.0, 2.7
Reader 2	n	19	19	19	18
	Mean (SD)	2.3 (0.7)	1.9 (0.7)	2.7 (1.0)	2.7 (1.0)
	Min, max	1.0, 3.7	1.0, 3.3	1.0, 4.0	1.0, 4.0
	95% CI	1.9, 2.6	1.6, 2.3	2.2, 3.2	2.2, 3.1
Reader 3	n	18	19	19	17
	Mean (SD)	1.8 (0.6)	2.9 (0.8)	2.9 (0.5)	2.8 (0.6)
	Min, max	1.0, 3.0	1.0, 4.0	2.0, 3.8	2.0, 4.0
	95% CI	1.5, 2.0	2.5, 3.3	2.6, 3.1	2.5, 3.1
LC
Reader 1	n	19	19	19	16
	Mean (SD)	1.9 (0.8)	2.8 (0.9)	2.8 (0.9)	3.0 (0.8)
	Min, max	1.0, 3.0	1.0, 4.0	1.0, 4.0	1.5, 4.0
	95% CI	1.5, 2.3	2.4, 3.3	2.4, 3.3	2.6, 3.4
Reader 2	n	19	19	19	18
	Mean (SD)	2.3 (0.7)	2.2 (0.7)	2.9 (0.9)	2.7 (0.9)
	Min, max	1.0, 3.0	1.0, 3.3	1.0, 4.0	1.0, 4.0
	95% CI	2.0, 2.6	1.9, 2.6	2.4, 3.3	2.2, 3.1
Reader 3	n	18	19	19	17
	Mean (SD)	1.8 (0.4)	3.3 (0.7)	3.3 (0.8)	3.2 (0.5)
	Min, max	1.0, 2.3	1.0, 4.0	1.0, 4.0	2.0, 4.0
	95% CI	1.5, 2.0	2.9, 3.6	2.9, 3.6	3.0, 3.5

Note: Patients without any detected lesions were excluded from the calculations. Mean scores are presented based on a 4-point qualitative scale (1 = poor, 2 = partial/moderate, 3 = good, 4 = excellent) used to evaluate lesion border delineation and lesion contrast. P values show a one-sided paired t test with a significance level of 0.025 Pr > t for the mean difference. CI, confidence interval; combined MRI, combined contrast enhanced MRI and unenhanced MRI; LBD, lesion border delineation; LC, lesion contrast; MRI, magnetic resonance imaging; N, total number of patients with a matched lesion for at least one of the readers; Pr, probability; SD, standard deviation.