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. 2002 Jul 18;99(16):10276–10281. doi: 10.1073/pnas.102327699

Fig 5.

Fig 5.

Duration of cross-desensitization induced by CCL5 or CXCL12. (A and B) CCL5 was administered into the PAG at the designated concentrations. After 60 min (A) or 120 min (B), DAMGO (400 ng; ▾) was administered, and the analgesic response was determined. (C and D) Alternatively, CXCL12 was administered into the PAG at the designated concentrations, and after 120 min (C) or 240 min (D), DAMGO (400 ng; ▾) was administered, and the analgesic response was determined. Results are presented as the mean ± SD and are representative of four independent experiments.