Table 7. Evaluation of the impact of MVPA-DTI modules on performance.

Method	AUROCa	AUPRb	F1-score	MCCc
w/od ProSFe	0.963	0.886	0.839	0.828
w/o DruSFf	0.964	0.891	0.840	0.827
w/o ProSF and DruSF	0.957	0.875	0.813	0.804
protBert-MVPA-DTIg	0.964	0.89	0.831	0.822
MVPA-DTIh	0.966	0.901	0.848	0.839

^aAUROC: Area Under the Receiver Operating Characteristic curve.

^bAUPR: Area Under the Precision-Recall Curve.

^cMCC: Matthews Correlation Coefficient.

^dw/o denotes corresponding module was removed.

^eProSF: protein sequence feature extraction module.

^fDruSF: drug compound structure feature extraction module.

^gprotBert-MVPA-DTI replaces the ProSF module with ProtBert processing.

^hMVPA-DTI: multi-view path aggregation for drug-target interaction.