Table 3-.
IC50 (μM) results of synthesized compounds.
| Compound | HeLa(μM) | MCF-7(μM) | HUVEC(μM) | Compound | HeLa(μM) | MCF-7(μM) | HUVEC(μM) |
|---|---|---|---|---|---|---|---|
| 1a | 187.13±1.52 | 204.65±3.74 | 270.15±5.12 | 5a | 170.67±1.43 | 161.31±0.92 | 291.79±4.60 |
| 1b | 206.94±0.31 | 193.27±0.22 | 224.90±0.32 | 5b | 195.25±1.32 | 169.19±5.31 | 231.32±1.36 |
| 1c | 208.18±2.07 | 203.04±3.81 | 233.56±1.41 | 5c | 193.41±0.51 | 156.03±2.01 | 258.89±8.69 |
| 1d | 194.92±0.19 | 212.28±5.74 | 263.05±8.18 | 5d | 154.46±2.53 | 180.32±4.88 | 307.1±4.86 |
| 1e | 193.29±3.46 | 216.58±0.90 | 312.45±7.26 | 5e | 174.83±3.34 | 142.52±5.35 | 285.17±1.96 |
| 1f | 186.29±4.94 | 190.04±4.06 | 332.98±2.24 | 5f | 174.05±0.16 | 150.65±1.51 | 295.42±3.42 |
| 1g | 188.75±1.13 | 199.87±2.72 | 300.57±2.76 | 5g | 171.51±2.37 | 150.56±1.10 | 249.46±8.16 |
| 2a | 164.34±2.78 | 154.43±4.63 | 270.86±3.12 | 6b | 70.37±5.89 | 70.35±3.11 | 74.03±1.81 |
| 2b | 197.55±5.15 | 144.65±1.51 | 251.98±9.80 | 6c | 58.41±0.86 | 53.27±2.96 | 86.20±1.67 |
| 2c | 196.55±2.15 | 203.12±0.95 | 244.71±4.12 | 6d | 46.57±2.30 | 36.88±0.84 | 92.90±3.78 |
| 2d | 176.69±4.41 | 169.40±3.61 | 271.77±3.71 | 6e | 45.01±3.55 | 24.01±2.61 | 103.48±4.57 |
| 2e | 166.17±3.83 | 144.39±3.94 | 269.98±4.67 | 6f | 34.55±2.11 | 34.72±3.44 | 107.42±2.91 |
| 2f | 193.70±0.26 | 137.14±2.41 | 272.86±8.04 | 6g | 33.99±1.75 | 28.31±2.85 | 109.3±3.49 |
| 2g | 175.49±2.27 | 165.66±3.11 | 274.47±2.30 | 6h | 38.45±1.68 | 30.86±1.17 | 109.66±3.38 |
| 3a | 169.17±2.75 | 180.99±0.93 | 262.92±7.22 | 7a | 60.39±2.73 | 58.98±1.65 | 121.08±1.99 |
| 3b | 176.75±1.01 | 155.81±1.17 | 282.54±8.66 | 7b | 45.14±3.27 | 35.34±2.49 | 107.14±2.51 |
| 3c | 191.66±0.63 | 171.6±2.95 | 260.05±2.71 | 7c | 25.89±3.56 | 18.53±0.86 | 110.41±1.20 |
| 3d | 192.75±3.41 | 172.77±6.20 | 250.99±0.88 | 7d | 12.68±1.49 | 10.83±0.68 | 106.75±2.31 |
| 3e | 165.47±4.66 | 148.87±2.81 | 261.22±2.84 | 7e | 24.34±0.19 | 19.87±1.75 | 106.40±3.32 |
| 3f | 194.09±3.06 | 132.72±0.53 | 352.99±2.92 | 7f | 14.88±0.63 | 19.50±1.48 | 96.89±2.85 |
| 3g | 110.70±4.37 | 153.55±5.25 | 285.37±9.55 | 7g | 19.76±2.69 | 14.16±1.07 | 96.03±1.74 |
| 4a | 178.62±1.27 | 163.51±3.12 | 271.29±7.48 | 7h | 29.32±0.62 | 26.40±1.67 | 85.98±2.37 |
| 4b | 182.73±0.70 | 134.68±3.19 | 226.82±3.01 | Doxorubicin | 1.45±0.15 | 17.44±0.04 | 93.00±0.54 |
| 4c | 202.46±1.54 | 139.41±6.89 | 248.49±0.34 | VER-155008 | 55.26±0.25 | 23.92±1.09 | 149.54±2.23 |
| 4d | 200.67±2.92 | 177.22±1.78 | 305.53±2.17 | FDI-6 | 18.88±0.89 | 25.76±2.41 | 240.26±1.14 |
| 4e | 185.50±3.00 | 115.63±0.43 | 328.56±1.95 | ||||
| 4f | 189.24±3.01 | 139.02±2.27 | 278.26±10.90 | ||||
| 4g | 160.59±2.45 | 162.06±4.88 | 248.28±3.94 |