Table 5.

Univariate and multivariate Cox regression analyses for OS.

Characteristics	Univariate analysis		Multivariate analysis
	HR, 95%CI	P value	HR, 95%CI	P value
Gender	1.163(0.795–1.702)	0.437
Male
Female
Age	1.145(0.837–1.566)	0.398
≥65
<65
Smoking status	1.006(0.717–1.412)	0.971
Yes
No
ECOG PS	1.216(0.839–1.764)	0.301
≥2
<2
Lung metastases	1.336(0.968–1.844)	0.078	1.161(0.764–1.764)	0.485
Yes
No
Bone metastases	1.139(0.827–1.570)	0.425
Yes
No
Brain metastases	1.049(0.726–1.517)	0.798
Yes
No
Liver metastases	2.058(1.442–2.939)	<0.001	1.816(1.227–2.688)	0.003
Yes
No
Number of metastatic lesions	1.759(1.209–2.559)	0.003	1.591(0.996–2.543)	0.052
≥3
<3
1L-ICIs	0.840(0.617–1.144)	0.268
Yes
No
1L-PFS (months)	0.618(0.453–0.843)	0.002	0.670(0.489–0.917)	0.013
≥6
<6