Table 1.

AIC and objective model function

Model number	Description	Objective function	AIC
1102_1	Base model: two-state; effect compartment, Emax ADC only; IIV on baseline	5638.663	5650.663
1102_3	Two-state: effect compartment, Emax ADC only, linear function for unconjugated MMAE; IIV on baseline	5594.443	5608.443
40073	Final model: Emax effect compartment of ADC, differing conditional effect across states; IIV on baseline; covariate model	5499.285	5525.285

AIC Akaike information criterion, ADC antibody–drug conjugate, E_max maximum effect, IIV interindividual variability, MMAE monomethyl auristatin E