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Phospholamban Ablation, SERCA2a Overexpression, and Improvements in Contraction, Relaxation, and Calcium Handling
| % Contraction | Contraction Velocity, %/s | Relaxation Velocity, %/s | τ, s | Cells, n | |
|---|---|---|---|---|---|
| Ad.βgal-GFP | 2.7 ± 1.0 | 8.7 ± 2.6 | 8.6 ± 4.3 | 0.6 ± 0.13 | 8 |
| Ad.asPL | 5.0 ± 0.9* | 20.3 ± 3.9* | 26.0 ± 6.2* | 0.29 ± 0.05* | 13 |
| Ad.SERCA2a | 4.9 ± 1.8* | 25.4 ± 8.8* | 27.4 ± 10.0* | 0.2 ± 0.04* | 9 |
τ indicates time course of relaxation as a function of increasing extracellular calcium.
P < 0.01 compared with Ad.βgal-GFP.
