Table 4.
Highly occuring COGs with pI varying across both the acidic and basic clusters. Table headers are the same as in Table 2.
| COG | P(a) | P(b) | P(v) | F | Role | Hbs | Eco | Hpy | Buc |
| COG0760 | 0.29 | 0.31 | 0.60 | O | Parvulin-like peptidyl-prolyl isomerase | - | 6.83 | 9.04 | 9.65 |
| COG0725 | 0.31 | 0.29 | 0.60 | P | ABC-type molybdate transport system, periplasmic component | 4.90 | 7.53 | 9.70 | - |
| COG0042 | 0.44 | 0.25 | 0.60 | R | Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family | 4.82 | 6.04 | 9.20 | - |
| COG0275 | 0.28 | 0.46 | 0.60 | M | Predicted S-adenosylmethionine-dependent methyltransferase | - | 5.92 | 8.99 | 9.93 |
| COG0258 | 0.69 | 0.30 | 0.61 | L | 5'-3' exonuclease (including N-terminal domain of PolI) | 4.06 | 5.74 | 9.06 | 9.59 |
| COG0640 | 0.38 | 0.28 | 0.61 | K | Predicted transcriptional regulators | 4.49 | 8.48 | - | - |
| COG0444 | 0.37 | 0.27 | 0.61 | E | ABC-type dipeptide/oligopeptide/nickel transport system, ATPase componen | 4.36 | 6.64 | 8.29 | - |
| COG0009 | 0.61 | 0.30 | 0.61 | J | Putative translation factor (SUA5) | 4.43 | 5.36 | - | 9.52 |
| COG0226 | 0.39 | 0.30 | 0.62 | P | ABC-type phosphate transport system, periplasmic component | 4.04 | 8.37 | - | - |
| COG1475 | 0.41 | 0.26 | 0.62 | K | Predicted transcriptional regulators | 4.46 | 6.78 | 8.39 | - |
| COG0190 | 0.51 | 0.30 | 0.62 | H | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase | 4.36 | 5.61 | 8.74 | 9.70 |
| COG1057 | 0.31 | 0.33 | 0.62 | H | Nicotinic acid mononucleotide adenylyltransferase | - | 5.38 | 8.80 | 9.68 |
| COG0482 | 0.42 | 0.28 | 0.62 | J | Predicted tRNA methyltransferase, contains the PP-loop ATPase domain | - | 4.89 | 8.82 | 9.50 |
| COG1121 | 0.29 | 0.35 | 0.62 | P | ABC-type Mn/Zn transport systems, ATPase component | 4.61 | 9.44 | - | 9.21 |
| COG0359 | 0.31 | 0.48 | 0.62 | J | Ribosomal protein L9 | - | 5.82 | 8.80 | 10.29 |
| COG0858 | 0.46 | 0.29 | 0.62 | J | Ribosome-binding factor A | - | 5.58 | 7.55 | 9.88 |
| COG0356 | 0.30 | 0.25 | 0.62 | C | F0F1-type ATP synthase a subunit | - | 6.18 | 6.34 | 7.64 |
| COG0501 | 0.29 | 0.41 | 0.63 | O | Zn-dependent protease with chaperone function | 7.18 | 7.10 | 7.86 | 6.91 |
| COG0350 | 0.31 | 0.46 | 0.64 | L | Methylated DNA-protein cysteine methyltransferase | 5.67 | 7.13 | 9.38 | - |
| COG1136 | 0.53 | 0.29 | 0.64 | R | ABC-type transport systems, involved in lipoprotein release, ATPase components | 6.85 | 6.66 | 9.03 | 7.53 |
| COG0816 | 0.26 | 0.36 | 0.64 | L | Predicted endonuclease involved in recombination | - | 6.21 | 9.05 | 9.81 |
| COG1159 | 0.36 | 0.26 | 0.64 | R | GTPases | - | 6.54 | 8.86 | 9.78 |
| COG0712 | 0.31 | 0.29 | 0.65 | C | F0F1-type ATP synthase delta subunit (mitochondrial oligomycin sensitivity protein) | - | 4.92 | 7.56 | 9.83 |
| COG1160 | 0.33 | 0.46 | 0.65 | R | Predicted GTPases | - | 5.62 | 9.15 | 9.92 |
| COG0463 | 0.31 | 0.55 | 0.66 | M | Glycosyltransferases involved in cell wall biogenesis | 4.80 | 8.55 | 8.87 | - |
| COG0324 | 0.34 | 0.30 | 0.66 | J | tRNA delta(2)-isopentenylpyrophosphate transferase | - | 5.58 | 9.56 | 9.58 |
| COG0617 | 0.32 | 0.36 | 0.66 | J | tRNA nucleotidyltransferase/poly(A) polymerase | - | 7.84 | 9.14 | 9.35 |
| COG1385 | 0.35 | 0.32 | 0.67 | S | Uncharacterized BCR | - | 6.80 | 9.08 | 9.71 |
| COG1825 | 0.34 | 0.34 | 0.67 | J | Ribosomal protein L25 (general stress protein Ctc) | - | 9.60 | 9.41 | 9.91 |
| COG0358 | 0.63 | 0.30 | 0.67 | L | DNA primase (bacterial type) | 4.35 | 5.62 | 8.97 | 9.48 |
| COG0593 | 0.42 | 0.32 | 0.69 | L | ATPase involved in DNA replication initiation | - | 6.97 | 8.35 | 9.55 |
| COG0052 | 0.64 | 0.33 | 0.69 | J | Ribosomal protein S2 | 4.06 | 6.38 | 6.82 | 9.61 |
| COG0616 | 0.49 | 0.32 | 0.69 | N | Periplasmic serine proteases (ClpP class) | 4.93 | 7.44 | 9.41 | 9.66 |
| COG0212 | 0.39 | 0.35 | 0.70 | H | 5-formyltetrahydrofolate cyclo-ligase | 4.42 | 6.10 | 9.98 | - |
| COG0470 | 0.59 | 0.34 | 0.70 | L | ATPase involved in DNA replication | 4.47 | 6.46 | 8.70 | 9.39 |
| COG1132 | 0.33 | 0.44 | 0.70 | Q | ABC-type multidrug/protein/lipid transport system, ATPase component | 4.43 | 6.91 | 9.23 | 9.60 |
| COG0750 | 0.33 | 0.52 | 0.71 | M | Predicted membrane-associated Zn-dependent proteases 1 | 4.91 | 6.41 | 9.18 | - |
| COG0341 | 0.36 | 0.40 | 0.71 | N | Preprotein translocase subunit SecF | 4.53 | 5.46 | 8.73 | - |
| COG0475 | 0.35 | 0.32 | 0.71 | P | Kef-type K+ transport systems, membrane components | - | 5.13 | 9.12 | - |
| COG0566 | 0.43 | 0.35 | 0.72 | J | rRNA methylases | - | 7.15 | 9.18 | - |
| COG0438 | 0.35 | 0.46 | 0.73 | M | Predicted glycosyltransferases | 4.96 | 8.21 | 8.66 | - |
| COG0223 | 0.43 | 0.36 | 0.73 | J | Methionyl-tRNA formyltransferase | - | 6.01 | 8.87 | 9.80 |
| COG0237 | 0.60 | 0.36 | 0.74 | H | Dephospho-CoA kinase 1 | 4.59 | 5.64 | 8.91 | 10.26 |
| COG0668 | 0.36 | 0.42 | 0.76 | M | Small-conductance mechanosensitive channel | 5.29 | 7.56 | 8.87 | 9.50 |
| COG0532 | 0.57 | 0.34 | 0.77 | J | Translation initiation factor 2 (GTPase) | 4.33 | 5.76 | 6.93 | 9.38 |
| COG0484 | 0.35 | 0.41 | 0.82 | O | Molecular chaperones (contain C-terminal Zn finger domain) | 4.54 | 7.94 | 8.12 | 9.17 |
| COG0164 | 0.39 | 0.44 | 0.83 | L | Ribonuclease H | 4.41 | 6.91 | 8.95 | - |
| COG0020 | 0.38 | 0.47 | 0.85 | I | Undecaprenyl pyrophosphate synthase | 5.11 | 6.29 | 8.97 | 9.45 |
| COG0681 | 0.41 | 0.49 | 0.86 | N | Signal peptidase | 4.99 | 6.46 | 8.34 | 9.51 |
| COG0244 | 0.40 | 0.53 | 0.87 | J | Ribosomal protein L10 | 3.80 | 9.04 | 9.36 | 9.98 |
| COG0130 | 0.45 | 0.43 | 0.88 | J | Pseudouridine synthase | 5.37 | 5.59 | - | 9.74 |
| Mean | 4.76 | 6.64 | 8.75 | 9.47 | |||||
| Standard Deviation | 0.7 | 1.14 | 0.73 | 0.69 |