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. 2025 Sep 22;16:1655598. doi: 10.3389/fendo.2025.1655598

Figure 3.

A series of graphs related to TGAb levels. Graph A shows a scatter plot with a slight negative correlation between TGAb (Log10 IU/mL) and Gorman diplopia score, with Rs equals negative 0.231 and p less than 0.05. Graph B is a box plot comparing TGAb levels in Absent and Present groups, showing significantly higher levels in the Present group, with p less than 0.01. Graph C is a ROC curve showing sensitivity versus 100% minus specificity, with the curve rising above the diagonal.

The correlation between TGAb and clinical characteristics in TRAb-negative TED Patient. (A) The negative correlation was evident between TGAb and Gorman diplopia score; (B) The TGAb level was significantly higher in the group with eyelid erythema symptoms compared to the group without symptoms at 18.39 (2.18, 40.32) IU/ml and 0.18 (0.00, 1.63) IU/ml, respectively, p < 0.01; (C) ROC curve analysis was performed using TGAb as the dependent variable and the presence of eyelid erythema as the outcome variable, yielding an AUC of 0.851 (95% CI: 0.721 – 0.980), p < 0.001, sensitivity of 0.778, specificity of 0.831, and a cutoff value of 3.980 IU/ml. TED, thyroid eye disease. TPOAb, thyroid peroxidase antibody. TGAb, thyroglobulin antibody. ROC, receiver operating characteristic. AUC, area under the curve.