TABLE 1.

Changes in levels and trends of availability, DDDs and DDDc.

	Evolocumab			Alirocumab
	Coefficient	P value	95% CI	Coefficient	P value	95% CI
Availability (%)
Baseline line (β0)	2.240	<0.001	1.497–2.982	−0.615	0.004	−1.028 to −0.202
Baseline trend (β1)	0.317	<0.001	0.268–0.367	0.154	<0.001	0.122–0.186
Level change immediately after intervention (β2)	13.031	<0.001	9.688–16.375	16.593	<0.001	12.018–21.168
Trend change after intervention (β3)	0.207	<0.001	−0.053–0.466	0.701	<0.001	0.409–0.992
Tertiary hospitals
Baseline line (β0)	3.356	<0.001	2.226–4.486	−0.839	0.003	−1.398 to −0.280
Baseline trend (β1)	0.447	<0.001	0.373–0.520	0.214	<0.001	0.171–0.257
Level change immediately after intervention (β2)	16.786	<0.001	12.447–21.124	20.188	<0.001	14.578–25.798
Trend change after intervention (β3)	0.126	0.466	−0.213–0.465	0.733	<0.001	0.367–1.099
Secondary hospitals
Baseline line (β0)	0.091	0.580	−0.231–0.413	−0.182	0.084	−0.389–0.024
Baseline trend (β1)	0.068	<0.001	0.039–0.096	0.039	0.003	0.013–0.065
Level change immediately after intervention (β2)	5.799	<0.001	4.101–7.498	9.669	<0.001	6.916–12.422
Trend change after intervention (β3)	0.362	<0.001	0.242–0.482	0.639	<0.001	0.474–0.803
DDDs
Baseline line (β0)	4262.020	0.115	−1039.870–9563.910	−2683.102	0.016	−4866.953 to −499.251
Baseline trend (β1)	2931.563	<0.001	2453.214–3409.913	833.907	<0.001	587.608–1080.206
Level change immediately after intervention (β2)	358427.900	<0.001	232729.700–484126.200	24277.340	0.392	−31268.960 to 79823.650
Trend change after intervention (β3)	74795.210	<0.001	63964.010–85626.420	46660.370	<0.001	43057.310–50263.440
Tertiary hospitals
Baseline line (β0)	4323.620	0.110	−976.642–9623.882	−2639.259	0.017	−4806.041 to −472.478
Baseline trend (β1)	2904.598	<0.001	2424.604–3384.502	825.012	<0.001	579.322–1071.702
Level change immediately after intervention (β2)	365058.700	<0.001	236118.200–493999.200	24228.410	0.365	−28149.180 to 76606.000
Trend change after intervention (β3)	71041.810	<0.001	60012.020–82071.610	43625.730	<0.001	40245.390–47006.060
Secondary hospitals
Baseline line (β0)	−61.600	0.161	−147.700–24.500	−43.843	0.052	−88.115–0.430
Baseline trend (β1)	26.965	<0.001	19.517–34.413	8.895	<0.001	4.284–13.506
Level change immediately after intervention (β2)	−6630.765	0.078	−14017.02–755.494	48.929	0.978	−3504.428–3602.287
Trend change after intervention (β3)	3753.400	<0.001	3280.144–4226.656	3034.650	<0.001	2736.776–3332.524
DDDc (CNY)
Baseline line (β0)	99.741	<0.001	93.829–105.652	96.732	0.007	26.252–167.213
Baseline trend (β1)	−1.083	0.001	−1.696–0.471	0.176	0.940	−4.403–4.755
Level change immediately after intervention (β2)	−53.587	<0.001	−63.746 to −43.428	−79.280	0.001	−127.234 to −31.324
Trend change after intervention (β3)	1.090	0.001	0.474–1.707	−0.154	0.948	−4.736–4.429

DDDs, Defined Daily Doses; DDDc, Defined Daily Dose cost; CNY, China Yuan; CI, confidence interval.