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. 2025 Sep 22;15:1653566. doi: 10.3389/fcimb.2025.1653566

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Copyright © 2025 Cai, Shang, Zheng, Chen, Xu, Chen, Wang, Wang, Chen, Cai, Zhang, Huang, Lin, Zhou, Lin, Zhang and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A. Dot plot showing increased signaling in MASLD, with axes for signaling pathways and cell types, colored by communication probability. B. Violin plots illustrating expression levels of CCL5, CCL3, and CCL4 across different cell populations in NL and MASLD groups. C. Bubble charts displaying KEGG and GO enrichment analysis for upregulated genes, with axes for pathways, activities, and gene ratios, colored by adjusted p-values. — Cellchat analysis and enrichment analysis of T cell subsets. (A) Dot plot of increased signaling in MASLD. (B) Expression levels of CCL3, CCL4, and CCL5 in T cell subsets. (C) Dot plot of KEGG enrichment analysis and GO enrichment analysis of upregulated genes in MASLD. (D) Dot plot of GO enrichment analysis of upregulated genes in MASLD.